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AKAP5 complex facilitates purinergic modulation of vascular L-type Ca(2+) channel Ca(V)1.2

The L-type Ca(2+) channel Ca(V)1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca(2+) channel via PKA, but the underlying mechanisms are unclear. Here, we find that cAMP synthesis in r...

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Detalles Bibliográficos
Autores principales:	Prada, Maria Paz, Syed, Arsalan U., Reddy, Gopireddy R., Martín-Aragón Baudel, Miguel, Flores-Tamez, Víctor A., Sasse, Kent C., Ward, Sean M., Sirish, Padmini, Chiamvimonvat, Nipavan, Bartels, Peter, Dickson, Eamonn J., Hell, Johannes W., Scott, John D., Santana, Luis F., Xiang, Yang K., Navedo, Manuel F., Nieves-Cintrón, Madeline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575592/ https://www.ncbi.nlm.nih.gov/pubmed/33082339 http://dx.doi.org/10.1038/s41467-020-18947-y

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