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Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation
Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Whioce Publishing Pte. Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575625/ https://www.ncbi.nlm.nih.gov/pubmed/33094188 http://dx.doi.org/10.18063/IJB.2017.02.004 |
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author | Sachan, Roger Jaipan, Panupong Zhang, Jennifer Y. Degan, Simone Erdmann, Detlev Tedesco, Jonathan Vanderwal, Lyndsi Stafslien, Shane J. Negut, Irina Visan, Anita Dorcioman, Gabriela Socol, Gabriel Cristescu, Rodica Chrisey, Douglas B. Narayan, Roger J. |
author_facet | Sachan, Roger Jaipan, Panupong Zhang, Jennifer Y. Degan, Simone Erdmann, Detlev Tedesco, Jonathan Vanderwal, Lyndsi Stafslien, Shane J. Negut, Irina Visan, Anita Dorcioman, Gabriela Socol, Gabriel Cristescu, Rodica Chrisey, Douglas B. Narayan, Roger J. |
author_sort | Sachan, Roger |
collection | PubMed |
description | Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles. |
format | Online Article Text |
id | pubmed-7575625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Whioce Publishing Pte. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75756252020-10-21 Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation Sachan, Roger Jaipan, Panupong Zhang, Jennifer Y. Degan, Simone Erdmann, Detlev Tedesco, Jonathan Vanderwal, Lyndsi Stafslien, Shane J. Negut, Irina Visan, Anita Dorcioman, Gabriela Socol, Gabriel Cristescu, Rodica Chrisey, Douglas B. Narayan, Roger J. Int J Bioprint Research Article Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a laser-based printing approach known as matrix-assisted pulsed laser evaporation to print amphotericin B on the surfaces of polyglycolic acid microneedles that were prepared using a combination of injection molding and drawing lithography. In a modified agar disk diffusion assay, the amphotericin B-loaded microneedles showed concentration-dependent activity against the yeast Candida albicans. The results of this study suggest that matrix-assisted pulsed laser evaporation may be used to print amphotericin B and other drugs that have complex solubility issues on the surfaces of microneedles. Whioce Publishing Pte. Ltd. 2017-07-14 /pmc/articles/PMC7575625/ /pubmed/33094188 http://dx.doi.org/10.18063/IJB.2017.02.004 Text en Copyright: © 2017 Sachan, et al. http://creativecommons.org/licenses/cc-by-nc/4.0/ This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Research Article Sachan, Roger Jaipan, Panupong Zhang, Jennifer Y. Degan, Simone Erdmann, Detlev Tedesco, Jonathan Vanderwal, Lyndsi Stafslien, Shane J. Negut, Irina Visan, Anita Dorcioman, Gabriela Socol, Gabriel Cristescu, Rodica Chrisey, Douglas B. Narayan, Roger J. Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title_full | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title_fullStr | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title_full_unstemmed | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title_short | Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation |
title_sort | printing amphotericin b on microneedles using matrix-assisted pulsed laser evaporation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575625/ https://www.ncbi.nlm.nih.gov/pubmed/33094188 http://dx.doi.org/10.18063/IJB.2017.02.004 |
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