Emerging Landscapes of Tumor Immunity and Metabolism

The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, imm...

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Autores principales: Wu, Fan, Cheng, Ye, Wu, Liangliang, Zhang, Wenling, Zheng, Wubing, Wang, Qian, Cao, Hongyong, Pan, Xiongxiong, Tang, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575711/
https://www.ncbi.nlm.nih.gov/pubmed/33117713
http://dx.doi.org/10.3389/fonc.2020.575037
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author Wu, Fan
Cheng, Ye
Wu, Liangliang
Zhang, Wenling
Zheng, Wubing
Wang, Qian
Cao, Hongyong
Pan, Xiongxiong
Tang, Weiwei
author_facet Wu, Fan
Cheng, Ye
Wu, Liangliang
Zhang, Wenling
Zheng, Wubing
Wang, Qian
Cao, Hongyong
Pan, Xiongxiong
Tang, Weiwei
author_sort Wu, Fan
collection PubMed
description The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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spelling pubmed-75757112020-10-27 Emerging Landscapes of Tumor Immunity and Metabolism Wu, Fan Cheng, Ye Wu, Liangliang Zhang, Wenling Zheng, Wubing Wang, Qian Cao, Hongyong Pan, Xiongxiong Tang, Weiwei Front Oncol Oncology The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment. Frontiers Media S.A. 2020-10-07 /pmc/articles/PMC7575711/ /pubmed/33117713 http://dx.doi.org/10.3389/fonc.2020.575037 Text en Copyright © 2020 Wu, Cheng, Wu, Zhang, Zheng, Wang, Cao, Pan and Tang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Fan
Cheng, Ye
Wu, Liangliang
Zhang, Wenling
Zheng, Wubing
Wang, Qian
Cao, Hongyong
Pan, Xiongxiong
Tang, Weiwei
Emerging Landscapes of Tumor Immunity and Metabolism
title Emerging Landscapes of Tumor Immunity and Metabolism
title_full Emerging Landscapes of Tumor Immunity and Metabolism
title_fullStr Emerging Landscapes of Tumor Immunity and Metabolism
title_full_unstemmed Emerging Landscapes of Tumor Immunity and Metabolism
title_short Emerging Landscapes of Tumor Immunity and Metabolism
title_sort emerging landscapes of tumor immunity and metabolism
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575711/
https://www.ncbi.nlm.nih.gov/pubmed/33117713
http://dx.doi.org/10.3389/fonc.2020.575037
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