Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans

Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin...

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Detalles Bibliográficos
Autores principales: Hornsby, Amanda K.E., Buntwal, Luke, Carisi, Maria Carla, Santos, Vanessa V., Johnston, Fionnuala, Roberts, Luke D., Sassi, Martina, Mequinion, Mathieu, Stark, Romana, Reichenbach, Alex, Lockie, Sarah H., Siervo, Mario, Howell, Owain, Morgan, Alwena H., Wells, Timothy, Andrews, Zane B., Burn, David J., Davies, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575905/
https://www.ncbi.nlm.nih.gov/pubmed/33103129
http://dx.doi.org/10.1016/j.xcrm.2020.100120

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