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Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

BACKGROUND: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficie...

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Autores principales: Onoyama, Takumi, Takeda, Yohei, Kawata, Soichiro, Kurumi, Hiroki, Koda, Hiroki, Yamashita, Taro, Hamamoto, Wataru, Sakamoto, Yuri, Matsumoto, Kazuya, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575990/
https://www.ncbi.nlm.nih.gov/pubmed/33145292
http://dx.doi.org/10.21037/atm-20-2738
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author Onoyama, Takumi
Takeda, Yohei
Kawata, Soichiro
Kurumi, Hiroki
Koda, Hiroki
Yamashita, Taro
Hamamoto, Wataru
Sakamoto, Yuri
Matsumoto, Kazuya
Isomoto, Hajime
author_facet Onoyama, Takumi
Takeda, Yohei
Kawata, Soichiro
Kurumi, Hiroki
Koda, Hiroki
Yamashita, Taro
Hamamoto, Wataru
Sakamoto, Yuri
Matsumoto, Kazuya
Isomoto, Hajime
author_sort Onoyama, Takumi
collection PubMed
description BACKGROUND: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficient amount of specimen at times. Therefore, we evaluated the adequate tissue acquisition rate and the factors affecting the adequate tissue acquisition of POCS-guided forceps biopsy for the biliary tract. METHODS: Patients who underwent POCS-guided forceps biopsy for biliary disease between September 2016 and October 2018 at our hospital were enrolled retrospectively. We evaluated the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion and that for non-stenotic bile duct. In addition, the factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy were evaluated. RESULTS: We enrolled 47 patients with biliary disease and performed POCS-guided forceps biopsy for biliary lesion and POCS-guided forceps mapping biopsy for non-stenotic bile duct in 40 and 36 patients, respectively. The adequate tissue acquisition rates of POCS-guided forceps biopsy for biliary lesions and that for non-stenotic bile duct were 86.4%, and 68.9%, respectively. In the multivariate logistic regression analyses, age, and previous biliary stenting before POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. For non-stenotic bile duct, the location of the biliary lesion, endoscopic sphincterotomy (EST), and procedure time of POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps mapping biopsy. CONCLUSIONS: Previous biliary stenting was a factor affecting a low tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. In the POCS-guided forceps mapping biopsy, the location of the biliary lesion, EST, and procedure time were factors affecting tissue acquisition rates.
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spelling pubmed-75759902020-11-02 Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy Onoyama, Takumi Takeda, Yohei Kawata, Soichiro Kurumi, Hiroki Koda, Hiroki Yamashita, Taro Hamamoto, Wataru Sakamoto, Yuri Matsumoto, Kazuya Isomoto, Hajime Ann Transl Med Original Article BACKGROUND: Peroral cholangioscopy (POCS)-guided forceps biopsy is a method for diagnosing indeterminate biliary strictures and for the preoperative identification of the exact perihilar and distal margins of biliary tract cancer (BTC). However, POCS-guided forceps biopsy may result in an insufficient amount of specimen at times. Therefore, we evaluated the adequate tissue acquisition rate and the factors affecting the adequate tissue acquisition of POCS-guided forceps biopsy for the biliary tract. METHODS: Patients who underwent POCS-guided forceps biopsy for biliary disease between September 2016 and October 2018 at our hospital were enrolled retrospectively. We evaluated the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion and that for non-stenotic bile duct. In addition, the factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy were evaluated. RESULTS: We enrolled 47 patients with biliary disease and performed POCS-guided forceps biopsy for biliary lesion and POCS-guided forceps mapping biopsy for non-stenotic bile duct in 40 and 36 patients, respectively. The adequate tissue acquisition rates of POCS-guided forceps biopsy for biliary lesions and that for non-stenotic bile duct were 86.4%, and 68.9%, respectively. In the multivariate logistic regression analyses, age, and previous biliary stenting before POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. For non-stenotic bile duct, the location of the biliary lesion, endoscopic sphincterotomy (EST), and procedure time of POCS were factors affecting the adequate tissue acquisition rate of POCS-guided forceps mapping biopsy. CONCLUSIONS: Previous biliary stenting was a factor affecting a low tissue acquisition rate of POCS-guided forceps biopsy for the biliary lesion. In the POCS-guided forceps mapping biopsy, the location of the biliary lesion, EST, and procedure time were factors affecting tissue acquisition rates. AME Publishing Company 2020-09 /pmc/articles/PMC7575990/ /pubmed/33145292 http://dx.doi.org/10.21037/atm-20-2738 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Onoyama, Takumi
Takeda, Yohei
Kawata, Soichiro
Kurumi, Hiroki
Koda, Hiroki
Yamashita, Taro
Hamamoto, Wataru
Sakamoto, Yuri
Matsumoto, Kazuya
Isomoto, Hajime
Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title_full Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title_fullStr Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title_full_unstemmed Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title_short Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
title_sort adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575990/
https://www.ncbi.nlm.nih.gov/pubmed/33145292
http://dx.doi.org/10.21037/atm-20-2738
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