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The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats

BACKGROUND: This study aimed to investigate the preventive effect of translocator protein 18kDa (TSPO) ligand PK11195 on amnestic mild cognitive impairment (aMCI), as well as its influence on astrocytes, in order to identify effective ways to prevent aMCI. METHODS: Male SD rats were randomly divided...

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Autores principales: Ye, Chen, Lin, Lanying, Zhang, Peiling, Chen, Yi, Huang, Jinghao, Lin, Xianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576013/
https://www.ncbi.nlm.nih.gov/pubmed/33241039
http://dx.doi.org/10.21037/atm-20-6157
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author Ye, Chen
Lin, Lanying
Zhang, Peiling
Chen, Yi
Huang, Jinghao
Lin, Xianzhong
author_facet Ye, Chen
Lin, Lanying
Zhang, Peiling
Chen, Yi
Huang, Jinghao
Lin, Xianzhong
author_sort Ye, Chen
collection PubMed
description BACKGROUND: This study aimed to investigate the preventive effect of translocator protein 18kDa (TSPO) ligand PK11195 on amnestic mild cognitive impairment (aMCI), as well as its influence on astrocytes, in order to identify effective ways to prevent aMCI. METHODS: Male SD rats were randomly divided into control group (n=10), aMCI group (n=10), PK11195 group (n=10), PK11195 + D-gal group (n=10). The preventive effect of PK11195 on aMCI in rats was evaluated. The cognitive function of rats in four different treatment groups was determined using the Morris water maze (MWM), as well as whole-brain pathology and immunofluorescence of rat brain tissue. RESULTS: The results of the MWM behavioral test showed that rats pre-treated with PK11195 had improved escape latency and a higher number of platform crossings compared with the aMCI model rats. PK11195 was also shown to prevent the D-galactose (D-gal)-induced senescence of pyramidal cells in the hippocampal CA1 region and to inhibit the apoptosis of astrocytes. At the same time, compared with the aMCI model rats, the TSPO in the brain tissue of rats pretreated with PK11195 had a lower distribution density. CONCLUSIONS: Our results prove that PK11195 can effectively prevent D-gal-induced decline of learning and memory function as well as inhibit abnormal changes of related cells.
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spelling pubmed-75760132020-11-24 The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats Ye, Chen Lin, Lanying Zhang, Peiling Chen, Yi Huang, Jinghao Lin, Xianzhong Ann Transl Med Original Article BACKGROUND: This study aimed to investigate the preventive effect of translocator protein 18kDa (TSPO) ligand PK11195 on amnestic mild cognitive impairment (aMCI), as well as its influence on astrocytes, in order to identify effective ways to prevent aMCI. METHODS: Male SD rats were randomly divided into control group (n=10), aMCI group (n=10), PK11195 group (n=10), PK11195 + D-gal group (n=10). The preventive effect of PK11195 on aMCI in rats was evaluated. The cognitive function of rats in four different treatment groups was determined using the Morris water maze (MWM), as well as whole-brain pathology and immunofluorescence of rat brain tissue. RESULTS: The results of the MWM behavioral test showed that rats pre-treated with PK11195 had improved escape latency and a higher number of platform crossings compared with the aMCI model rats. PK11195 was also shown to prevent the D-galactose (D-gal)-induced senescence of pyramidal cells in the hippocampal CA1 region and to inhibit the apoptosis of astrocytes. At the same time, compared with the aMCI model rats, the TSPO in the brain tissue of rats pretreated with PK11195 had a lower distribution density. CONCLUSIONS: Our results prove that PK11195 can effectively prevent D-gal-induced decline of learning and memory function as well as inhibit abnormal changes of related cells. AME Publishing Company 2020-09 /pmc/articles/PMC7576013/ /pubmed/33241039 http://dx.doi.org/10.21037/atm-20-6157 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Ye, Chen
Lin, Lanying
Zhang, Peiling
Chen, Yi
Huang, Jinghao
Lin, Xianzhong
The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title_full The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title_fullStr The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title_full_unstemmed The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title_short The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
title_sort protective effect of pk11195 on d-galactose-induced amnestic mild cognitive impairment in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576013/
https://www.ncbi.nlm.nih.gov/pubmed/33241039
http://dx.doi.org/10.21037/atm-20-6157
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