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Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship

Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To...

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Autor principal: Holló, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576041/
https://www.ncbi.nlm.nih.gov/pubmed/33241052
http://dx.doi.org/10.21037/atm.2020.03.187
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author Holló, Gábor
author_facet Holló, Gábor
author_sort Holló, Gábor
collection PubMed
description Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To ensure that treatment is efficient and tailored to the actual needs both cross sectional evaluation of disease severity and measurement of rate of progression are essential. Currently staging and progression are investigated with visual field and retinal thickness measurements. Perimetry, however, is influenced by several biological factors which are not related to glaucoma, and the use of retinal thinning is limited by floor effect. Therefore, clinical application of optical retinal coherence tomography angiography, a new and rapidly developing non-invasive measurement of the capillary perfusion in the various retinal layers, respectively, is now in the focus of clinical glaucoma research. This comprehensive review summarizes the current knowledge on one of the most important research areas in optical coherence tomography angiography in glaucoma, the relationship between retinal capillary perfusion and the spatially corresponding visual field threshold sensitivity.
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spelling pubmed-75760412020-11-24 Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship Holló, Gábor Ann Transl Med Review Article on OCT Angiography in Glaucoma Glaucoma, a well-defined group of progressive optic neuropathies is one of the leading causes of irreversible blindness worldwide. In order to stop or slow down the progression of glaucomatous vision deterioration, intraocular pressure reduction by medical, laser or surgical treatment is needed. To ensure that treatment is efficient and tailored to the actual needs both cross sectional evaluation of disease severity and measurement of rate of progression are essential. Currently staging and progression are investigated with visual field and retinal thickness measurements. Perimetry, however, is influenced by several biological factors which are not related to glaucoma, and the use of retinal thinning is limited by floor effect. Therefore, clinical application of optical retinal coherence tomography angiography, a new and rapidly developing non-invasive measurement of the capillary perfusion in the various retinal layers, respectively, is now in the focus of clinical glaucoma research. This comprehensive review summarizes the current knowledge on one of the most important research areas in optical coherence tomography angiography in glaucoma, the relationship between retinal capillary perfusion and the spatially corresponding visual field threshold sensitivity. AME Publishing Company 2020-09 /pmc/articles/PMC7576041/ /pubmed/33241052 http://dx.doi.org/10.21037/atm.2020.03.187 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article on OCT Angiography in Glaucoma
Holló, Gábor
Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title_full Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title_fullStr Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title_full_unstemmed Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title_short Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
title_sort optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship
topic Review Article on OCT Angiography in Glaucoma
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576041/
https://www.ncbi.nlm.nih.gov/pubmed/33241052
http://dx.doi.org/10.21037/atm.2020.03.187
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