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Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity
Cell-cycle entry relies on an orderly progression of signaling events. To start, cells first activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb. Hours later, cells inactivate APC/C(CDH1) and cross the final commitment point. However, many cells...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576148/ https://www.ncbi.nlm.nih.gov/pubmed/33082317 http://dx.doi.org/10.1038/s41467-020-18966-9 |