Lamin A safeguards the m(6)A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence

Mutations in LMNA gene are frequently identified in patients suffering from a genetic disorder known as Hutchison–Gilford progeria syndrome (HGPS), providing an ideal model for the understanding of the mechanisms of aging. Lamin A, encoded by LMNA, is an essential component of the subnuclear domain‒...

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Detalles Bibliográficos
Autores principales: Zhang, Jie, Ao, Ying, Zhang, Zhen, Mo, Yanzhen, Peng, Linyuan, Jiang, Yue, Wang, Zimei, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576246/
https://www.ncbi.nlm.nih.gov/pubmed/32813328
http://dx.doi.org/10.1111/acel.13215

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