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The phenotypic changes of γδ T cells in COVID‐19 patients

A novel pneumonia‐associated respiratory syndrome named coronavirus disease‐2019 (COVID‐19), which was caused by SARS‐CoV‐2,broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS‐CoV‐2 infections. The information regardin...

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Autores principales: Lei, Lei, Qian, Hongbo, Yang, Xiaofang, Zhang, Xingzhe, Zhang, Dan, Dai, Tongxin, Guo, Rui, Shi, Lin, Cheng, Yanbin, Zhang, Baojun, Zhou, Xiaobo, Hu, Jinsong, Guo, Yaling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576249/
https://www.ncbi.nlm.nih.gov/pubmed/32864865
http://dx.doi.org/10.1111/jcmm.15620
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author Lei, Lei
Qian, Hongbo
Yang, Xiaofang
Zhang, Xingzhe
Zhang, Dan
Dai, Tongxin
Guo, Rui
Shi, Lin
Cheng, Yanbin
Zhang, Baojun
Zhou, Xiaobo
Hu, Jinsong
Guo, Yaling
author_facet Lei, Lei
Qian, Hongbo
Yang, Xiaofang
Zhang, Xingzhe
Zhang, Dan
Dai, Tongxin
Guo, Rui
Shi, Lin
Cheng, Yanbin
Zhang, Baojun
Zhou, Xiaobo
Hu, Jinsong
Guo, Yaling
author_sort Lei, Lei
collection PubMed
description A novel pneumonia‐associated respiratory syndrome named coronavirus disease‐2019 (COVID‐19), which was caused by SARS‐CoV‐2,broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS‐CoV‐2 infections. The information regarding the immunological characteristics in COVID‐19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID‐19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS‐CoV‐2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS‐CoV‐2 infection.
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spelling pubmed-75762492020-10-23 The phenotypic changes of γδ T cells in COVID‐19 patients Lei, Lei Qian, Hongbo Yang, Xiaofang Zhang, Xingzhe Zhang, Dan Dai, Tongxin Guo, Rui Shi, Lin Cheng, Yanbin Zhang, Baojun Zhou, Xiaobo Hu, Jinsong Guo, Yaling J Cell Mol Med Short Communications A novel pneumonia‐associated respiratory syndrome named coronavirus disease‐2019 (COVID‐19), which was caused by SARS‐CoV‐2,broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS‐CoV‐2 infections. The information regarding the immunological characteristics in COVID‐19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID‐19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS‐CoV‐2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS‐CoV‐2 infection. John Wiley and Sons Inc. 2020-08-30 2020-10 /pmc/articles/PMC7576249/ /pubmed/32864865 http://dx.doi.org/10.1111/jcmm.15620 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Lei, Lei
Qian, Hongbo
Yang, Xiaofang
Zhang, Xingzhe
Zhang, Dan
Dai, Tongxin
Guo, Rui
Shi, Lin
Cheng, Yanbin
Zhang, Baojun
Zhou, Xiaobo
Hu, Jinsong
Guo, Yaling
The phenotypic changes of γδ T cells in COVID‐19 patients
title The phenotypic changes of γδ T cells in COVID‐19 patients
title_full The phenotypic changes of γδ T cells in COVID‐19 patients
title_fullStr The phenotypic changes of γδ T cells in COVID‐19 patients
title_full_unstemmed The phenotypic changes of γδ T cells in COVID‐19 patients
title_short The phenotypic changes of γδ T cells in COVID‐19 patients
title_sort phenotypic changes of γδ t cells in covid‐19 patients
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576249/
https://www.ncbi.nlm.nih.gov/pubmed/32864865
http://dx.doi.org/10.1111/jcmm.15620
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