Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways

Fibrotic remodeling has become the result of many lung diseases, and these disorders can be categorized with known as well as unknown etiologies. Idiopathic pulmonary fibrosis is the most fatal disease among the unknown etiology. TGFβ1/Smad3 signal pathway plays an important role in lung fibrosis an...

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Autores principales: Wang, Wei, Liu, Zhaoheng, Niu, Jie, Yang, Haojie, Long, Qi, Liu, Haoge, Gu, Xiaofeng, Jiao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576352/
https://www.ncbi.nlm.nih.gov/pubmed/33101446
http://dx.doi.org/10.1155/2020/5814658
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author Wang, Wei
Liu, Zhaoheng
Niu, Jie
Yang, Haojie
Long, Qi
Liu, Haoge
Gu, Xiaofeng
Jiao, Yang
author_facet Wang, Wei
Liu, Zhaoheng
Niu, Jie
Yang, Haojie
Long, Qi
Liu, Haoge
Gu, Xiaofeng
Jiao, Yang
author_sort Wang, Wei
collection PubMed
description Fibrotic remodeling has become the result of many lung diseases, and these disorders can be categorized with known as well as unknown etiologies. Idiopathic pulmonary fibrosis is the most fatal disease among the unknown etiology. TGFβ1/Smad3 signal pathway plays an important role in lung fibrosis and epithelial regeneration. This study investigated the effects and mechanism of Feibi Recipe (FBR) on pulmonary fibrosis. In this experiment, C57BL/6 mice were used and bleomycin was used to induce the lung injury. Meanwhile, the study showed a significant reduction in pathological response and mediators of inflammation and fibrosis such as IL-6, ICAM-1, IL-13, IL-17, BRP-39, TGFβ1, Smad3, and Smad7 were identified. Collectively, the FBR appears to attenuate the lung injury and the modeling of fibrosis in mice.
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spelling pubmed-75763522020-10-22 Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways Wang, Wei Liu, Zhaoheng Niu, Jie Yang, Haojie Long, Qi Liu, Haoge Gu, Xiaofeng Jiao, Yang Evid Based Complement Alternat Med Research Article Fibrotic remodeling has become the result of many lung diseases, and these disorders can be categorized with known as well as unknown etiologies. Idiopathic pulmonary fibrosis is the most fatal disease among the unknown etiology. TGFβ1/Smad3 signal pathway plays an important role in lung fibrosis and epithelial regeneration. This study investigated the effects and mechanism of Feibi Recipe (FBR) on pulmonary fibrosis. In this experiment, C57BL/6 mice were used and bleomycin was used to induce the lung injury. Meanwhile, the study showed a significant reduction in pathological response and mediators of inflammation and fibrosis such as IL-6, ICAM-1, IL-13, IL-17, BRP-39, TGFβ1, Smad3, and Smad7 were identified. Collectively, the FBR appears to attenuate the lung injury and the modeling of fibrosis in mice. Hindawi 2020-10-12 /pmc/articles/PMC7576352/ /pubmed/33101446 http://dx.doi.org/10.1155/2020/5814658 Text en Copyright © 2020 Wei Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Wei
Liu, Zhaoheng
Niu, Jie
Yang, Haojie
Long, Qi
Liu, Haoge
Gu, Xiaofeng
Jiao, Yang
Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title_full Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title_fullStr Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title_full_unstemmed Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title_short Feibi Recipe Reduced Pulmonary Fibrosis Induced by Bleomycin in Mice by Regulating BRP39/IL-17 and TGFβ1/Smad3 Signal Pathways
title_sort feibi recipe reduced pulmonary fibrosis induced by bleomycin in mice by regulating brp39/il-17 and tgfβ1/smad3 signal pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576352/
https://www.ncbi.nlm.nih.gov/pubmed/33101446
http://dx.doi.org/10.1155/2020/5814658
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