Cargando…

Hydroxy-Propil-β-Cyclodextrin Inclusion Complexes of two Biphenylnicotinamide Derivatives: Formulation and Anti-Proliferative Activity Evaluation in Pancreatic Cancer Cell Models

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with poor outcomes largely due to its unique microenvironment, which is responsible for the low response to drugs and drug-resistance phenomena. This clinical need led us to explore new therapeutic approaches for sys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iacobazzi, Rosa Maria, Cutrignelli, Annalisa, Stefanachi, Angela, Porcelli, Letizia, Lopedota, Angela Assunta, Di Fonte, Roberta, Lopalco, Antonio, Serratì, Simona, Laquintana, Valentino, Silvestris, Nicola, Franco, Massimo, Cellamare, Saverio, Leonetti, Francesco, Azzariti, Amalia, Denora, Nunzio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576480/ https://www.ncbi.nlm.nih.gov/pubmed/32906812 http://dx.doi.org/10.3390/ijms21186545

Ejemplares similares

Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights
por: Iacobazzi, Rosa Maria, et al.
Publicado: (2021)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Transferrin Functionalized Liposomes Loading Dopamine HCl: Development and Permeability Studies across an In Vitro Model of Human Blood–Brain Barrier
por: Lopalco, Antonio, et al.
Publicado: (2018)

Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML
por: Carofiglio, Francesca, et al.
Publicado: (2020)

Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide
por: Pistone, Monica, et al.
Publicado: (2022)

Stability data of extemporaneous suspensions of hydroxychloroquine sulphate in oral liquid bases after tablet manipulation
por: Perrone, Mara, et al.
Publicado: (2020)

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels
por: Lopalco, Antonio, et al.
Publicado: (2018)

The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia
por: Maqoud, Fatima, et al.
Publicado: (2020)

Dasatinib/HP-β-CD Inclusion Complex Based Aqueous Formulation as a Promising Tool for the Treatment of Paediatric Neuromuscular Disorders
por: Cutrignelli, Annalisa, et al.
Publicado: (2019)

Exploring the Microfluidic Production of Biomimetic Hybrid Nanoparticles and Their Pharmaceutical Applications
por: Fondaj, Dafina, et al.
Publicado: (2023)

CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer
por: Porcelli, Letizia, et al.
Publicado: (2019)

In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use
por: Lopalco, Antonio, et al.
Publicado: (2022)

A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders
por: Perrone, Mara, et al.
Publicado: (2016)

Digital Technologies Applied to Control the One-Step Process of Cannabis Olive Oil Preparations
por: Bongiorno, Paolo, et al.
Publicado: (2023)

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture
por: Serrati, Simona, et al.
Publicado: (2020)

Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position
por: Savino, Salvatore, et al.
Publicado: (2016)

The Pharmaceutical Technology Approach on Imaging Innovations from Italian Research
por: Ailuno, Giorgia, et al.
Publicado: (2021)

Editorial: What does it take to cure the brain? Studies toward genes, proteins, processes, and rehabilitation
por: Shu, Xinhua, et al.
Publicado: (2023)

Effectiveness of a Controlled 5-FU Delivery Based on FZD10 Antibody-Conjugated Liposomes in Colorectal Cancer In vitro Models
por: Scavo, Maria Principia, et al.
Publicado: (2020)

Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity
por: Porcelli, Letizia, et al.
Publicado: (2017)

Radiosynthesis and characterization of [(18)F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
por: Lee, Sang Hee, et al.
Publicado: (2021)

Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases
por: Bettiol, Alessandra, et al.
Publicado: (2019)

Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation
por: Depalo, Nicoletta, et al.
Publicado: (2019)

Fabrication of photoactive heterostructures based on quantum dots decorated with Au nanoparticles
por: Fanizza, Elisabetta, et al.
Publicado: (2016)

β-Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation
por: Mantuano, Paola, et al.
Publicado: (2021)

Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma
por: Serratì, Simona, et al.
Publicado: (2022)

Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells
por: Zeineh, Nidal, et al.
Publicado: (2020)

The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson’s Disease
por: Monga, Sheelu, et al.
Publicado: (2021)

Paediatric Formulation: Design and Development
por: Lopalco, Antonio, et al.
Publicado: (2020)

New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity
por: Barbanente, Alessandra, et al.
Publicado: (2021)

Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study
por: Argentiero, Antonella, et al.
Publicado: (2019)

The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer
por: Danza, Katia, et al.
Publicado: (2021)

Plasma-activated medium triggers cell death and the presentation of immune activating danger signals in melanoma and pancreatic cancer cells
por: Azzariti, Amalia, et al.
Publicado: (2019)

Editorial: Coumarins: New synthetic approaches and new pharmacological applications
por: Stefanachi, Angela, et al.
Publicado: (2023)

The Interaction between Reactive Peritoneal Mesothelial Cells and Tumor Cells via Extracellular Vesicles Facilitates Colorectal Cancer Dissemination
por: Serratì, Simona, et al.
Publicado: (2021)

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting
por: Fanizza, Elisabetta, et al.
Publicado: (2019)

Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma
por: Azzariti, Amalia, et al.
Publicado: (2016)

Oxcarbazepine-loaded polymeric nanoparticles: development and permeability studies across in vitro models of the blood–brain barrier and human placental trophoblast
por: Lopalco, Antonio, et al.
Publicado: (2015)

Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma
por: Serratì, Simona, et al.
Publicado: (2020)

Interest of preoperative immunonutrition in liver resection for cancer: study protocol of the PROPILS trial, a multicenter randomized controlled phase IV trial
por: Ciacio, Oriana, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_es1g9d1cdv7dogvlc8oaitsk7m