Cargando…
Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice
Background: In developed countries, the extension of human life is increasingly accompanied by a progressive increase in neurodegenerative diseases, most of which do not yet have effective therapy but only symptomatic treatments. In recent years, plant polyphenols have aroused considerable interest...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576486/ https://www.ncbi.nlm.nih.gov/pubmed/32899274 http://dx.doi.org/10.3390/antiox9090824 |
_version_ | 1783598024547631104 |
---|---|
author | Siracusa, Rosalba Scuto, Maria Fusco, Roberta Trovato, Angela Ontario, Maria Laura Crea, Roberto Di Paola, Rosanna Cuzzocrea, Salvatore Calabrese, Vittorio |
author_facet | Siracusa, Rosalba Scuto, Maria Fusco, Roberta Trovato, Angela Ontario, Maria Laura Crea, Roberto Di Paola, Rosanna Cuzzocrea, Salvatore Calabrese, Vittorio |
author_sort | Siracusa, Rosalba |
collection | PubMed |
description | Background: In developed countries, the extension of human life is increasingly accompanied by a progressive increase in neurodegenerative diseases, most of which do not yet have effective therapy but only symptomatic treatments. In recent years, plant polyphenols have aroused considerable interest in the scientific community. The mechanisms currently hypothesized for the pathogenesis of Parkinson’s disease (PD) are neuroinflammation, oxidative stress and apoptosis. Hydroxytyrosol (HT), the main component of Hidrox(®) (HD), has been shown to have some of the highest free radical evacuation and anti-inflammatory activities. Here we wanted to study the role of HD on the neurobiological and behavioral alterations induced by rotenone. Methods: A study was conducted in which mice received HD (10 mg/kg, i.p.) concomitantly with rotenone (5 mg/kg, o.s.) for 28 days. Results: Locomotor activity, catalepsy, histological damage and several characteristic markers of the PD, such as the dopamine transporter (DAT) content, tyrosine hydroxylase (TH) and accumulation of α-synuclein, have been evaluated. Moreover, we observed the effects of HD on oxidative stress, neuroinflammation, apoptosis and inflammasomes. Taken together, the results obtained highlight HD’s ability to reduce the loss of dopaminergic neurons and the damage associated with it by counteracting the three main mechanisms of PD pathogenesis. Conclusion: HD is subject to fewer regulations than traditional drugs to improve patients’ brain health and could represent a promising nutraceutical choice to prevent PD. |
format | Online Article Text |
id | pubmed-7576486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75764862020-10-28 Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice Siracusa, Rosalba Scuto, Maria Fusco, Roberta Trovato, Angela Ontario, Maria Laura Crea, Roberto Di Paola, Rosanna Cuzzocrea, Salvatore Calabrese, Vittorio Antioxidants (Basel) Article Background: In developed countries, the extension of human life is increasingly accompanied by a progressive increase in neurodegenerative diseases, most of which do not yet have effective therapy but only symptomatic treatments. In recent years, plant polyphenols have aroused considerable interest in the scientific community. The mechanisms currently hypothesized for the pathogenesis of Parkinson’s disease (PD) are neuroinflammation, oxidative stress and apoptosis. Hydroxytyrosol (HT), the main component of Hidrox(®) (HD), has been shown to have some of the highest free radical evacuation and anti-inflammatory activities. Here we wanted to study the role of HD on the neurobiological and behavioral alterations induced by rotenone. Methods: A study was conducted in which mice received HD (10 mg/kg, i.p.) concomitantly with rotenone (5 mg/kg, o.s.) for 28 days. Results: Locomotor activity, catalepsy, histological damage and several characteristic markers of the PD, such as the dopamine transporter (DAT) content, tyrosine hydroxylase (TH) and accumulation of α-synuclein, have been evaluated. Moreover, we observed the effects of HD on oxidative stress, neuroinflammation, apoptosis and inflammasomes. Taken together, the results obtained highlight HD’s ability to reduce the loss of dopaminergic neurons and the damage associated with it by counteracting the three main mechanisms of PD pathogenesis. Conclusion: HD is subject to fewer regulations than traditional drugs to improve patients’ brain health and could represent a promising nutraceutical choice to prevent PD. MDPI 2020-09-03 /pmc/articles/PMC7576486/ /pubmed/32899274 http://dx.doi.org/10.3390/antiox9090824 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Siracusa, Rosalba Scuto, Maria Fusco, Roberta Trovato, Angela Ontario, Maria Laura Crea, Roberto Di Paola, Rosanna Cuzzocrea, Salvatore Calabrese, Vittorio Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title | Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title_full | Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title_fullStr | Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title_full_unstemmed | Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title_short | Anti-inflammatory and Anti-oxidant Activity of Hidrox(®) in Rotenone-Induced Parkinson’s Disease in Mice |
title_sort | anti-inflammatory and anti-oxidant activity of hidrox(®) in rotenone-induced parkinson’s disease in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576486/ https://www.ncbi.nlm.nih.gov/pubmed/32899274 http://dx.doi.org/10.3390/antiox9090824 |
work_keys_str_mv | AT siracusarosalba antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT scutomaria antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT fuscoroberta antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT trovatoangela antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT ontariomarialaura antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT crearoberto antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT dipaolarosanna antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT cuzzocreasalvatore antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice AT calabresevittorio antiinflammatoryandantioxidantactivityofhidroxinrotenoneinducedparkinsonsdiseaseinmice |