Cargando…

Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation

The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors continues to limit Tx efficacy. In this project, we demonstrate a novel approach aimed at protecting islets before T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pomposelli, Thomas, Wang, Ping, Takeuchi, Kazuhiro, Miyake, Katsunori, Ariyoshi, Yuichi, Watanabe, Hironosuke, Chen, Xiaojuan, Shimizu, Akira, Robertson, Neil, Yamada, Kazuhiko, Moore, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576559/ https://www.ncbi.nlm.nih.gov/pubmed/32855170 http://dx.doi.org/10.2337/db20-0517

Ejemplares similares

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
por: Nyqvist, Daniel, et al.
Publicado: (2011)

A Theranostic Small Interfering RNA Nanoprobe Protects Pancreatic Islet Grafts From Adoptively Transferred Immune Rejection
por: Wang, Ping, et al.
Publicado: (2012)

Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization
por: Henriksnäs, Johanna, et al.
Publicado: (2012)

Increased Numbers of Low-Oxygenated Pancreatic Islets After Intraportal Islet Transplantation
por: Olsson, Richard, et al.
Publicado: (2011)

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
por: Silva, Diego G., et al.
Publicado: (2011)

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to That in Native Islets
por: Christoffersson, Gustaf, et al.
Publicado: (2010)

Rituximab Selectively Suppresses Specific Islet Antibodies
por: Yu, Liping, et al.
Publicado: (2011)

Hematopoietic Stem Cell Mobilization Is Necessary but Not Sufficient for Tolerance in Islet Transplantation
por: Stocks, Blair T., et al.
Publicado: (2017)

Viral Infection of Engrafted Human Islets Leads to Diabetes
por: Gallagher, Glen R., et al.
Publicado: (2015)

Effectiveness of Intraoperative Versus Dedicated Islet Cell Laboratory Isolation for Total Pancreatectomy With Islet Autotransplant
por: Navas, Christopher M., et al.
Publicado: (2022)

Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons
por: Hawthorne, W J, et al.
Publicado: (2014)

A Strategy to Simultaneously Cure Type 1 Diabetes and Diabetic Nephropathy by Transplant of Composite Islet-Kidney Grafts
por: Pomposelli, Thomas, et al.
Publicado: (2021)

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice: Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
por: Akirav, Eitan M., et al.
Publicado: (2011)

The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes
por: Elvers, Karen T., et al.
Publicado: (2013)

Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation
por: Wang, Ping, et al.
Publicado: (2011)

Optimizing Porcine Islet Isolation to Markedly Reduce Enzyme Consumption Without Sacrificing Islet Yield or Function
por: Holdcraft, Robert W., et al.
Publicado: (2016)

Redox Modulation Protects Islets From Transplant-Related Injury
por: Sklavos, Martha M., et al.
Publicado: (2010)

Cognitive Outcome After Islet Transplantation
por: Mailliez, Aurélie, et al.
Publicado: (2023)

Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
por: Kang, Shinae, et al.
Publicado: (2012)

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates
por: Berman, Dora M., et al.
Publicado: (2010)

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
por: Arif, Sefina, et al.
Publicado: (2014)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile
por: Yeung, Wing-Chi G., et al.
Publicado: (2012)

Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
por: Rickels, Michael R., et al.
Publicado: (2015)

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
por: McGuire, Helen M., et al.
Publicado: (2011)

Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold
por: Berman, Dora M., et al.
Publicado: (2016)

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes
por: Kwon, Bum Chul, et al.
Publicado: (2022)

Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients
por: Robertson, R. Paul, et al.
Publicado: (2015)

Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons
por: Hawthorne, Wayne J., et al.
Publicado: (2022)

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
por: Mangada, Julie, et al.
Publicado: (2009)

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
por: Alkemade, Gonnie M., et al.
Publicado: (2013)

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
por: Arif, Sefina, et al.
Publicado: (2011)

Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes
por: Zhang, Chunyan, et al.
Publicado: (2010)

Successful Islet Transplantation Into a Subcutaneous Polycaprolactone Scaffold in Mice and Pigs
por: Smink, Alexandra M., et al.
Publicado: (2022)

Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation
por: Vallabhajosyula, Prashanth, et al.
Publicado: (2018)

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
por: Olerud, Johan, et al.
Publicado: (2008)

Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses
por: Carvello, Michele, et al.
Publicado: (2012)

Australia and New Zealand Islets and Pancreas Transplant Registry Annual Report 2017—Pancreas Waiting List, Recipients, and Donors
por: Webster, Angela C, et al.
Publicado: (2017)

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
por: Dai, Yang D., et al.
Publicado: (2009)

Inhibition of Gelatinase B (Matrix Metalloprotease-9) Activity Reduces Cellular Inflammation and Restores Function of Transplanted Pancreatic Islets
por: Lingwal, Neelam, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_af9btdjv3iuefjqqbsn19use1b