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VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress
Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage. VMAT2 plays a role in modulating insulin release by regulating dopamine levels in the pancreas, although the exact mechanism remains elusive. We found that VMAT2 expression in β-cells specifically inc...
Autores principales: | Sakano, Daisuke, Uefune, Fumiya, Tokuma, Hiraku, Sonoda, Yuki, Matsuura, Kumi, Takeda, Naoki, Nakagata, Naomi, Kume, Kazuhiko, Shiraki, Nobuaki, Kume, Shoen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576560/ https://www.ncbi.nlm.nih.gov/pubmed/32826296 http://dx.doi.org/10.2337/db20-0207 |
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