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Emerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576599/ https://www.ncbi.nlm.nih.gov/pubmed/33082313 http://dx.doi.org/10.1038/s41419-020-03069-6 |
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author | Wang, Dongying He, Jiaxing Huang, Bingyu Liu, Shanshan Zhu, Hongming Xu, Tianmin |
author_facet | Wang, Dongying He, Jiaxing Huang, Bingyu Liu, Shanshan Zhu, Hongming Xu, Tianmin |
author_sort | Wang, Dongying |
collection | PubMed |
description | Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant biological properties in controlling organ size, tissue homeostasis, and regeneration. Recently, the Hippo-YAP axis has been extensively referred to as the pathophysiological processes regulating autophagy. Understanding the cellular and molecular basis of these processes is crucial for identifying disease pathogenesis and novel therapeutic targets. Here we review recent findings from Drosophila models to organisms. We particularly emphasize the regulation between Hippo core components and autophagy, which is involved in normal cellular regulation and the pathogenesis of human diseases, and its application to disease treatment. |
format | Online Article Text |
id | pubmed-7576599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75765992020-10-23 Emerging role of the Hippo pathway in autophagy Wang, Dongying He, Jiaxing Huang, Bingyu Liu, Shanshan Zhu, Hongming Xu, Tianmin Cell Death Dis Review Article Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant biological properties in controlling organ size, tissue homeostasis, and regeneration. Recently, the Hippo-YAP axis has been extensively referred to as the pathophysiological processes regulating autophagy. Understanding the cellular and molecular basis of these processes is crucial for identifying disease pathogenesis and novel therapeutic targets. Here we review recent findings from Drosophila models to organisms. We particularly emphasize the regulation between Hippo core components and autophagy, which is involved in normal cellular regulation and the pathogenesis of human diseases, and its application to disease treatment. Nature Publishing Group UK 2020-10-20 /pmc/articles/PMC7576599/ /pubmed/33082313 http://dx.doi.org/10.1038/s41419-020-03069-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Wang, Dongying He, Jiaxing Huang, Bingyu Liu, Shanshan Zhu, Hongming Xu, Tianmin Emerging role of the Hippo pathway in autophagy |
title | Emerging role of the Hippo pathway in autophagy |
title_full | Emerging role of the Hippo pathway in autophagy |
title_fullStr | Emerging role of the Hippo pathway in autophagy |
title_full_unstemmed | Emerging role of the Hippo pathway in autophagy |
title_short | Emerging role of the Hippo pathway in autophagy |
title_sort | emerging role of the hippo pathway in autophagy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576599/ https://www.ncbi.nlm.nih.gov/pubmed/33082313 http://dx.doi.org/10.1038/s41419-020-03069-6 |
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