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The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study

AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multic...

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Autores principales: Just, Katja S., Dormann, Harald, Schurig, Marlen, Böhme, Miriam, Steffens, Michael, Plank‐Kiegele, Bettina, Ettrich, Kristin, Seufferlein, Thomas, Gräff, Ingo, Igel, Svitlana, Schricker, Severin, Jaeger, Simon U., Schwab, Matthias, Stingl, Julia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576634/
https://www.ncbi.nlm.nih.gov/pubmed/32250457
http://dx.doi.org/10.1111/bcp.14304
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author Just, Katja S.
Dormann, Harald
Schurig, Marlen
Böhme, Miriam
Steffens, Michael
Plank‐Kiegele, Bettina
Ettrich, Kristin
Seufferlein, Thomas
Gräff, Ingo
Igel, Svitlana
Schricker, Severin
Jaeger, Simon U.
Schwab, Matthias
Stingl, Julia C.
author_facet Just, Katja S.
Dormann, Harald
Schurig, Marlen
Böhme, Miriam
Steffens, Michael
Plank‐Kiegele, Bettina
Ettrich, Kristin
Seufferlein, Thomas
Gräff, Ingo
Igel, Svitlana
Schricker, Severin
Jaeger, Simon U.
Schwab, Matthias
Stingl, Julia C.
author_sort Just, Katja S.
collection PubMed
description AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multicentre prospective observational study (ADRED) were analysed (n = 2215). We analysed ADR‐associated diagnoses, symptoms and their risk profiles. We present frequencies and odds ratios (OR) with 95% confidence intervals for adults (18–64 years) compared to older adults (≥65 years; young–old 65–79, old–old ≥80 years) and regression coefficients (B) for each year of age. RESULTS: Most prominent differences were seen for drug‐associated confusion, dehydration, and bradycardia (OR 6.70 [1.59–28.27], B .054; OR 6.02 [2.41–15.03], B .081, and 4.82 [2.21–10.54], B .040), more likely seen in older adults. Bleedings were reported in all age groups, but gastrointestinal bleedings occurred with more than doubled chance in older adults (OR 2.46 [1.77–3.41], B .030), likewise did other bleedings such as haemorrhage from respiratory passages (OR 2.89 [1.37–6.11], B.036). Falls were more likely in older adults (OR 2.84 [1.77–4.53], B .030), while dizziness was frequent in both age groups. CONCLUSION: Our data point to differences in symptoms of ADRs between adults and older individuals, with dangerous drug‐associated phenomena in the older adult such as bleedings or falls. Physicians should consider drug‐associated origins of symptoms in older adults with an increased risk for serious health problems.
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spelling pubmed-75766342020-10-23 The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study Just, Katja S. Dormann, Harald Schurig, Marlen Böhme, Miriam Steffens, Michael Plank‐Kiegele, Bettina Ettrich, Kristin Seufferlein, Thomas Gräff, Ingo Igel, Svitlana Schricker, Severin Jaeger, Simon U. Schwab, Matthias Stingl, Julia C. Br J Clin Pharmacol Original Articles AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multicentre prospective observational study (ADRED) were analysed (n = 2215). We analysed ADR‐associated diagnoses, symptoms and their risk profiles. We present frequencies and odds ratios (OR) with 95% confidence intervals for adults (18–64 years) compared to older adults (≥65 years; young–old 65–79, old–old ≥80 years) and regression coefficients (B) for each year of age. RESULTS: Most prominent differences were seen for drug‐associated confusion, dehydration, and bradycardia (OR 6.70 [1.59–28.27], B .054; OR 6.02 [2.41–15.03], B .081, and 4.82 [2.21–10.54], B .040), more likely seen in older adults. Bleedings were reported in all age groups, but gastrointestinal bleedings occurred with more than doubled chance in older adults (OR 2.46 [1.77–3.41], B .030), likewise did other bleedings such as haemorrhage from respiratory passages (OR 2.89 [1.37–6.11], B.036). Falls were more likely in older adults (OR 2.84 [1.77–4.53], B .030), while dizziness was frequent in both age groups. CONCLUSION: Our data point to differences in symptoms of ADRs between adults and older individuals, with dangerous drug‐associated phenomena in the older adult such as bleedings or falls. Physicians should consider drug‐associated origins of symptoms in older adults with an increased risk for serious health problems. John Wiley and Sons Inc. 2020-04-24 2020-11 /pmc/articles/PMC7576634/ /pubmed/32250457 http://dx.doi.org/10.1111/bcp.14304 Text en © 2020 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Just, Katja S.
Dormann, Harald
Schurig, Marlen
Böhme, Miriam
Steffens, Michael
Plank‐Kiegele, Bettina
Ettrich, Kristin
Seufferlein, Thomas
Gräff, Ingo
Igel, Svitlana
Schricker, Severin
Jaeger, Simon U.
Schwab, Matthias
Stingl, Julia C.
The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title_full The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title_fullStr The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title_full_unstemmed The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title_short The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
title_sort phenotype of adverse drug effects: do emergency visits due to adverse drug reactions look different in older people? results from the adred study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576634/
https://www.ncbi.nlm.nih.gov/pubmed/32250457
http://dx.doi.org/10.1111/bcp.14304
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