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The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multic...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576634/ https://www.ncbi.nlm.nih.gov/pubmed/32250457 http://dx.doi.org/10.1111/bcp.14304 |
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author | Just, Katja S. Dormann, Harald Schurig, Marlen Böhme, Miriam Steffens, Michael Plank‐Kiegele, Bettina Ettrich, Kristin Seufferlein, Thomas Gräff, Ingo Igel, Svitlana Schricker, Severin Jaeger, Simon U. Schwab, Matthias Stingl, Julia C. |
author_facet | Just, Katja S. Dormann, Harald Schurig, Marlen Böhme, Miriam Steffens, Michael Plank‐Kiegele, Bettina Ettrich, Kristin Seufferlein, Thomas Gräff, Ingo Igel, Svitlana Schricker, Severin Jaeger, Simon U. Schwab, Matthias Stingl, Julia C. |
author_sort | Just, Katja S. |
collection | PubMed |
description | AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multicentre prospective observational study (ADRED) were analysed (n = 2215). We analysed ADR‐associated diagnoses, symptoms and their risk profiles. We present frequencies and odds ratios (OR) with 95% confidence intervals for adults (18–64 years) compared to older adults (≥65 years; young–old 65–79, old–old ≥80 years) and regression coefficients (B) for each year of age. RESULTS: Most prominent differences were seen for drug‐associated confusion, dehydration, and bradycardia (OR 6.70 [1.59–28.27], B .054; OR 6.02 [2.41–15.03], B .081, and 4.82 [2.21–10.54], B .040), more likely seen in older adults. Bleedings were reported in all age groups, but gastrointestinal bleedings occurred with more than doubled chance in older adults (OR 2.46 [1.77–3.41], B .030), likewise did other bleedings such as haemorrhage from respiratory passages (OR 2.89 [1.37–6.11], B.036). Falls were more likely in older adults (OR 2.84 [1.77–4.53], B .030), while dizziness was frequent in both age groups. CONCLUSION: Our data point to differences in symptoms of ADRs between adults and older individuals, with dangerous drug‐associated phenomena in the older adult such as bleedings or falls. Physicians should consider drug‐associated origins of symptoms in older adults with an increased risk for serious health problems. |
format | Online Article Text |
id | pubmed-7576634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75766342020-10-23 The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study Just, Katja S. Dormann, Harald Schurig, Marlen Böhme, Miriam Steffens, Michael Plank‐Kiegele, Bettina Ettrich, Kristin Seufferlein, Thomas Gräff, Ingo Igel, Svitlana Schricker, Severin Jaeger, Simon U. Schwab, Matthias Stingl, Julia C. Br J Clin Pharmacol Original Articles AIMS: Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. METHODS: Cases of ADRs in emergency departments collected within the multicentre prospective observational study (ADRED) were analysed (n = 2215). We analysed ADR‐associated diagnoses, symptoms and their risk profiles. We present frequencies and odds ratios (OR) with 95% confidence intervals for adults (18–64 years) compared to older adults (≥65 years; young–old 65–79, old–old ≥80 years) and regression coefficients (B) for each year of age. RESULTS: Most prominent differences were seen for drug‐associated confusion, dehydration, and bradycardia (OR 6.70 [1.59–28.27], B .054; OR 6.02 [2.41–15.03], B .081, and 4.82 [2.21–10.54], B .040), more likely seen in older adults. Bleedings were reported in all age groups, but gastrointestinal bleedings occurred with more than doubled chance in older adults (OR 2.46 [1.77–3.41], B .030), likewise did other bleedings such as haemorrhage from respiratory passages (OR 2.89 [1.37–6.11], B.036). Falls were more likely in older adults (OR 2.84 [1.77–4.53], B .030), while dizziness was frequent in both age groups. CONCLUSION: Our data point to differences in symptoms of ADRs between adults and older individuals, with dangerous drug‐associated phenomena in the older adult such as bleedings or falls. Physicians should consider drug‐associated origins of symptoms in older adults with an increased risk for serious health problems. John Wiley and Sons Inc. 2020-04-24 2020-11 /pmc/articles/PMC7576634/ /pubmed/32250457 http://dx.doi.org/10.1111/bcp.14304 Text en © 2020 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Just, Katja S. Dormann, Harald Schurig, Marlen Böhme, Miriam Steffens, Michael Plank‐Kiegele, Bettina Ettrich, Kristin Seufferlein, Thomas Gräff, Ingo Igel, Svitlana Schricker, Severin Jaeger, Simon U. Schwab, Matthias Stingl, Julia C. The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title | The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title_full | The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title_fullStr | The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title_full_unstemmed | The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title_short | The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study |
title_sort | phenotype of adverse drug effects: do emergency visits due to adverse drug reactions look different in older people? results from the adred study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576634/ https://www.ncbi.nlm.nih.gov/pubmed/32250457 http://dx.doi.org/10.1111/bcp.14304 |
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