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CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8(+) T cells via NF-κB signaling
BACKGROUND: CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied. METHODS: Foxp3(+) and CD8(+) T cells in GCs were investigated using immunohistochemistry (IHC). CD137 expression in GCs was detect...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576737/ https://www.ncbi.nlm.nih.gov/pubmed/33093811 http://dx.doi.org/10.1186/s12935-020-01605-0 |