EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To investigate the effects of post-translational modifications on EVI1 function, we carried out...

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Detalles Bibliográficos
Autores principales: Paredes, Roberto, Kelly, James R., Geary, Bethany, Almarzouq, Batool, Schneider, Marion, Pearson, Stella, Narayanan, Prakrithi, Williamson, Andrew, Lovell, Simon C., Wiseman, Daniel H., Chadwick, John A., Jones, Nigel J., Kustikova, Olga, Schambach, Axel, Garner, Terence, Amaral, Fabio M. R., Pierce, Andrew, Stevens, Adam, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576810/
https://www.ncbi.nlm.nih.gov/pubmed/33082307
http://dx.doi.org/10.1038/s41419-020-03099-0

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