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Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study
BACKGROUND: Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregn...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576815/ https://www.ncbi.nlm.nih.gov/pubmed/33101701 http://dx.doi.org/10.1186/s40748-020-00119-x |
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author | Kassem, Zeinab Sitarik, Alexandra Levin, Albert M. Lynch, Susan V. Havstad, Suzanne Fujimura, Kei Kozyrskyj, Anita Ownby, Dennis R. Johnson, Christine Cole Yong, Germaine J. M. Wegienka, Ganesa Cassidy-Bushrow, Andrea E. |
author_facet | Kassem, Zeinab Sitarik, Alexandra Levin, Albert M. Lynch, Susan V. Havstad, Suzanne Fujimura, Kei Kozyrskyj, Anita Ownby, Dennis R. Johnson, Christine Cole Yong, Germaine J. M. Wegienka, Ganesa Cassidy-Bushrow, Andrea E. |
author_sort | Kassem, Zeinab |
collection | PubMed |
description | BACKGROUND: Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregnancy or at delivery (cord blood) and infant gut microbiota. METHODS: Maternal and cord blood 25[OH]D levels were assessed in a sample of pregnant women. Compositional analyses adjusted for race were run on the gut microbiota of their offspring at 1 and 6 months of age. RESULTS: Mean prenatal 25(OH)D level was 25.04 ± 11.62 ng/mL and mean cord blood 25(OH)D level was 10.88 ± 6.77 ng/mL. Increasing prenatal 25(OH)D level was significantly associated with decreased richness (p = 0.028) and diversity (p = 0.012) of the gut microbiota at 1 month of age. Both prenatal and cord 25(OH)D were significantly associated with 1 month microbiota composition. A total of 6 operational taxonomic units (OTUs) were significantly associated with prenatal 25(OH)D level (four positively and two negatively) while 11 OTUs were significantly associated with cord 25(OH)D (10 positively and one negatively). Of these, OTU 93 (Acinetobacter) and OTU 210 (Corynebacterium), were consistently positively associated with maternal and cord 25(OH)D; OTU 64 (Ruminococcus gnavus) was positively associated with prenatal 25(OH)D but negatively associated with cord 25(OH)D. CONCLUSIONS: Prenatal maternal and cord blood 25(OH)D levels are associated with the early life gut microbiota. Future studies are needed to understand how vitamin D and the microbiome may interact to influence child health. |
format | Online Article Text |
id | pubmed-7576815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75768152020-10-22 Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study Kassem, Zeinab Sitarik, Alexandra Levin, Albert M. Lynch, Susan V. Havstad, Suzanne Fujimura, Kei Kozyrskyj, Anita Ownby, Dennis R. Johnson, Christine Cole Yong, Germaine J. M. Wegienka, Ganesa Cassidy-Bushrow, Andrea E. Matern Health Neonatol Perinatol Research Article BACKGROUND: Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregnancy or at delivery (cord blood) and infant gut microbiota. METHODS: Maternal and cord blood 25[OH]D levels were assessed in a sample of pregnant women. Compositional analyses adjusted for race were run on the gut microbiota of their offspring at 1 and 6 months of age. RESULTS: Mean prenatal 25(OH)D level was 25.04 ± 11.62 ng/mL and mean cord blood 25(OH)D level was 10.88 ± 6.77 ng/mL. Increasing prenatal 25(OH)D level was significantly associated with decreased richness (p = 0.028) and diversity (p = 0.012) of the gut microbiota at 1 month of age. Both prenatal and cord 25(OH)D were significantly associated with 1 month microbiota composition. A total of 6 operational taxonomic units (OTUs) were significantly associated with prenatal 25(OH)D level (four positively and two negatively) while 11 OTUs were significantly associated with cord 25(OH)D (10 positively and one negatively). Of these, OTU 93 (Acinetobacter) and OTU 210 (Corynebacterium), were consistently positively associated with maternal and cord 25(OH)D; OTU 64 (Ruminococcus gnavus) was positively associated with prenatal 25(OH)D but negatively associated with cord 25(OH)D. CONCLUSIONS: Prenatal maternal and cord blood 25(OH)D levels are associated with the early life gut microbiota. Future studies are needed to understand how vitamin D and the microbiome may interact to influence child health. BioMed Central 2020-10-20 /pmc/articles/PMC7576815/ /pubmed/33101701 http://dx.doi.org/10.1186/s40748-020-00119-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Kassem, Zeinab Sitarik, Alexandra Levin, Albert M. Lynch, Susan V. Havstad, Suzanne Fujimura, Kei Kozyrskyj, Anita Ownby, Dennis R. Johnson, Christine Cole Yong, Germaine J. M. Wegienka, Ganesa Cassidy-Bushrow, Andrea E. Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title | Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title_full | Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title_fullStr | Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title_full_unstemmed | Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title_short | Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study |
title_sort | maternal and cord blood vitamin d level and the infant gut microbiota in a birth cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576815/ https://www.ncbi.nlm.nih.gov/pubmed/33101701 http://dx.doi.org/10.1186/s40748-020-00119-x |
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