UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

BACKGROUND: Radioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response (DDR), which includes DNA repair and cell cycle checkpoints activation, leads to radioresistance and limits radiotherapy efficacy in HCC patients. Howe...

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Detalles Bibliográficos
Autores principales: Sun, Jingyuan, Zhu, Zhenru, Li, Wenwen, Shen, Mengying, Cao, Chuanhui, Sun, Qingcan, Guo, Zeqin, Liu, Li, Wu, Dehua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576867/
https://www.ncbi.nlm.nih.gov/pubmed/33087136
http://dx.doi.org/10.1186/s13046-020-01734-4

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