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Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal Fat at Different Postnatal Ages
The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epidid...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Developmental Biology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576962/ https://www.ncbi.nlm.nih.gov/pubmed/33110948 http://dx.doi.org/10.12717/DR.2020.24.3.167 |
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author | Lee, Ki-Ho |
author_facet | Lee, Ki-Ho |
author_sort | Lee, Ki-Ho |
collection | PubMed |
description | The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epididymal fat at different postnatal ages, including 2, 5, 8, and 12 months of age. The quantitative real-time PCR analysis showed continuous increases of expression levels of delta like non-canonical Notch ligand 1, leptin, and resistin as postnatally aged. The transcript level of peroxisome proliferator-activated receptor gamma was the highest at 5 months of age, remaining at a steady level until 12 months of age. Expression levels of fatty acid binding protein 4, leptin, and adiponectin were significantly increased until 8 months of age, persisting the level at 12 months of age. The transcript level of fatty acid synthase was significantly increased at 8 months of age, without a further change of the level at 12 months of age. These findings exhibited the expression of adipocyte-associated genes which were also detected at the ordinary epididymal fat pad. However, expression patterns of these genes in the tail epididymal fat are different with those in the distal and proximal epididymal fat, suggesting distinct characteristics and/or functions of the tail epididymal fat. |
format | Online Article Text |
id | pubmed-7576962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Developmental Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-75769622020-10-26 Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal Fat at Different Postnatal Ages Lee, Ki-Ho Dev Reprod Research Articles The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epididymal fat at different postnatal ages, including 2, 5, 8, and 12 months of age. The quantitative real-time PCR analysis showed continuous increases of expression levels of delta like non-canonical Notch ligand 1, leptin, and resistin as postnatally aged. The transcript level of peroxisome proliferator-activated receptor gamma was the highest at 5 months of age, remaining at a steady level until 12 months of age. Expression levels of fatty acid binding protein 4, leptin, and adiponectin were significantly increased until 8 months of age, persisting the level at 12 months of age. The transcript level of fatty acid synthase was significantly increased at 8 months of age, without a further change of the level at 12 months of age. These findings exhibited the expression of adipocyte-associated genes which were also detected at the ordinary epididymal fat pad. However, expression patterns of these genes in the tail epididymal fat are different with those in the distal and proximal epididymal fat, suggesting distinct characteristics and/or functions of the tail epididymal fat. Korean Society of Developmental Biology 2020-09 2020-09-30 /pmc/articles/PMC7576962/ /pubmed/33110948 http://dx.doi.org/10.12717/DR.2020.24.3.167 Text en © Copyright 2020 The Korean Society of Developmental Biology http://creative-commons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creative-commons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Lee, Ki-Ho Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal Fat at Different Postnatal Ages |
title | Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal
Fat at Different Postnatal Ages |
title_full | Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal
Fat at Different Postnatal Ages |
title_fullStr | Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal
Fat at Different Postnatal Ages |
title_full_unstemmed | Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal
Fat at Different Postnatal Ages |
title_short | Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal
Fat at Different Postnatal Ages |
title_sort | expression of adipocyte-associated genes in the mouse tail epididymal
fat at different postnatal ages |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576962/ https://www.ncbi.nlm.nih.gov/pubmed/33110948 http://dx.doi.org/10.12717/DR.2020.24.3.167 |
work_keys_str_mv | AT leekiho expressionofadipocyteassociatedgenesinthemousetailepididymalfatatdifferentpostnatalages |