Immunological considerations for SARS-CoV-2 human challenge studies

The ethics and practicalities of controlled human infection with SARS-CoV-2 have been widely discussed. Potential risks are clear. The case in favour hinges upon whether these risks can be mitigated to an acceptable, very low, level and whether the studies will provide substantial benefits that coul...

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Detalles Bibliográficos
Autores principales: Douglas, Alexander D., Hill, Adrian V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576971/
https://www.ncbi.nlm.nih.gov/pubmed/33087904
http://dx.doi.org/10.1038/s41577-020-00472-0
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author Douglas, Alexander D.
Hill, Adrian V. S.
author_facet Douglas, Alexander D.
Hill, Adrian V. S.
author_sort Douglas, Alexander D.
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description The ethics and practicalities of controlled human infection with SARS-CoV-2 have been widely discussed. Potential risks are clear. The case in favour hinges upon whether these risks can be mitigated to an acceptable, very low, level and whether the studies will provide substantial benefits that could not readily be obtained by other means. Here, we discuss the immunological considerations relating to each side of this balance.
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spelling pubmed-75769712020-10-22 Immunological considerations for SARS-CoV-2 human challenge studies Douglas, Alexander D. Hill, Adrian V. S. Nat Rev Immunol Comment The ethics and practicalities of controlled human infection with SARS-CoV-2 have been widely discussed. Potential risks are clear. The case in favour hinges upon whether these risks can be mitigated to an acceptable, very low, level and whether the studies will provide substantial benefits that could not readily be obtained by other means. Here, we discuss the immunological considerations relating to each side of this balance. Nature Publishing Group UK 2020-10-21 2020 /pmc/articles/PMC7576971/ /pubmed/33087904 http://dx.doi.org/10.1038/s41577-020-00472-0 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Douglas, Alexander D.
Hill, Adrian V. S.
Immunological considerations for SARS-CoV-2 human challenge studies
title Immunological considerations for SARS-CoV-2 human challenge studies
title_full Immunological considerations for SARS-CoV-2 human challenge studies
title_fullStr Immunological considerations for SARS-CoV-2 human challenge studies
title_full_unstemmed Immunological considerations for SARS-CoV-2 human challenge studies
title_short Immunological considerations for SARS-CoV-2 human challenge studies
title_sort immunological considerations for sars-cov-2 human challenge studies
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576971/
https://www.ncbi.nlm.nih.gov/pubmed/33087904
http://dx.doi.org/10.1038/s41577-020-00472-0
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