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New insights into testicular granulosa cell tumors

Testicular granulosa cell tumors (TGCTs) are rare tumors of sex cord-stromal origin. TGCTs are mostly benign and can be classified into the adult type and the juvenile type. Due to the rarity of clinical cases and limited research efforts, the mechanism underpinning the development of TGCTs remains...

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Autores principales: Fang, Xin, Li, Qinglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576989/
https://www.ncbi.nlm.nih.gov/pubmed/33101487
http://dx.doi.org/10.3892/ol.2020.12156
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author Fang, Xin
Li, Qinglei
author_facet Fang, Xin
Li, Qinglei
author_sort Fang, Xin
collection PubMed
description Testicular granulosa cell tumors (TGCTs) are rare tumors of sex cord-stromal origin. TGCTs are mostly benign and can be classified into the adult type and the juvenile type. Due to the rarity of clinical cases and limited research efforts, the mechanism underpinning the development of TGCTs remains poorly understood. A landmark study has identified a forkhead box L2 mutation (C134W) in nearly all adult ovarian GCTs, but its implications in TGCTs are unclear. The present study focuses on reviewing the major signaling pathways (e.g., the transforming growth factor β signaling pathway) critical for the development of TGCTs, as revealed by genetically modified mouse models, with a goal of providing new insights into the pathogenesis of TGCTs and offering directions for future studies in this area. We posit that a comparative approach between testicular and ovarian GCTs is valuable, as granulosa cells and Sertoli cells arise from the same progenitor cells during gonadal development. Developing pre-clinical mouse models that recapitulate TGCTs will help answer the remaining questions around this type of rare tumor.
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spelling pubmed-75769892020-10-22 New insights into testicular granulosa cell tumors Fang, Xin Li, Qinglei Oncol Lett Review Testicular granulosa cell tumors (TGCTs) are rare tumors of sex cord-stromal origin. TGCTs are mostly benign and can be classified into the adult type and the juvenile type. Due to the rarity of clinical cases and limited research efforts, the mechanism underpinning the development of TGCTs remains poorly understood. A landmark study has identified a forkhead box L2 mutation (C134W) in nearly all adult ovarian GCTs, but its implications in TGCTs are unclear. The present study focuses on reviewing the major signaling pathways (e.g., the transforming growth factor β signaling pathway) critical for the development of TGCTs, as revealed by genetically modified mouse models, with a goal of providing new insights into the pathogenesis of TGCTs and offering directions for future studies in this area. We posit that a comparative approach between testicular and ovarian GCTs is valuable, as granulosa cells and Sertoli cells arise from the same progenitor cells during gonadal development. Developing pre-clinical mouse models that recapitulate TGCTs will help answer the remaining questions around this type of rare tumor. D.A. Spandidos 2020-12 2020-09-25 /pmc/articles/PMC7576989/ /pubmed/33101487 http://dx.doi.org/10.3892/ol.2020.12156 Text en Copyright: © Fang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Fang, Xin
Li, Qinglei
New insights into testicular granulosa cell tumors
title New insights into testicular granulosa cell tumors
title_full New insights into testicular granulosa cell tumors
title_fullStr New insights into testicular granulosa cell tumors
title_full_unstemmed New insights into testicular granulosa cell tumors
title_short New insights into testicular granulosa cell tumors
title_sort new insights into testicular granulosa cell tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576989/
https://www.ncbi.nlm.nih.gov/pubmed/33101487
http://dx.doi.org/10.3892/ol.2020.12156
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