The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38(high) T cell subset i...

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Detalles Bibliográficos
Autores principales: Katsuyama, Eri, Suarez-Fueyo, Abel, Bradley, Sean J., Mizui, Masayuki, Marin, Ana V., Mulki, Lama, Krishfield, Suzanne, Malavasi, Fabio, Yoon, Joon, Ho Sui, Shannan J., Kyttaris, Vasileios C., Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577012/
https://www.ncbi.nlm.nih.gov/pubmed/31914379
http://dx.doi.org/10.1016/j.celrep.2019.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577012/
https://www.ncbi.nlm.nih.gov/pubmed/31914379
http://dx.doi.org/10.1016/j.celrep.2019.12.014

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