Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome se...

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Detalles Bibliográficos
Autores principales: Reichmuth, Martina L., Hömke, Rico, Zürcher, Kathrin, Sander, Peter, Avihingsanon, Anchalee, Collantes, Jimena, Loiseau, Chloé, Borrell, Sonia, Reinhard, Miriam, Wilkinson, Robert J., Yotebieng, Marcel, Fenner, Lukas, Böttger, Erik C., Gagneux, Sebastien, Egger, Matthias, Keller, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577131/
https://www.ncbi.nlm.nih.gov/pubmed/32868333
http://dx.doi.org/10.1128/AAC.00513-20
Descripción
Sumario:Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC.

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