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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients
Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome se...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577131/ https://www.ncbi.nlm.nih.gov/pubmed/32868333 http://dx.doi.org/10.1128/AAC.00513-20 |
| _version_ | 1783598146938470400 |
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| author | Reichmuth, Martina L. Hömke, Rico Zürcher, Kathrin Sander, Peter Avihingsanon, Anchalee Collantes, Jimena Loiseau, Chloé Borrell, Sonia Reinhard, Miriam Wilkinson, Robert J. Yotebieng, Marcel Fenner, Lukas Böttger, Erik C. Gagneux, Sebastien Egger, Matthias Keller, Peter M. |
| author_facet | Reichmuth, Martina L. Hömke, Rico Zürcher, Kathrin Sander, Peter Avihingsanon, Anchalee Collantes, Jimena Loiseau, Chloé Borrell, Sonia Reinhard, Miriam Wilkinson, Robert J. Yotebieng, Marcel Fenner, Lukas Böttger, Erik C. Gagneux, Sebastien Egger, Matthias Keller, Peter M. |
| author_sort | Reichmuth, Martina L. |
| collection | PubMed |
| description | Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC. |
| format | Online Article Text |
| id | pubmed-7577131 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75771312020-10-30 Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients Reichmuth, Martina L. Hömke, Rico Zürcher, Kathrin Sander, Peter Avihingsanon, Anchalee Collantes, Jimena Loiseau, Chloé Borrell, Sonia Reinhard, Miriam Wilkinson, Robert J. Yotebieng, Marcel Fenner, Lukas Böttger, Erik C. Gagneux, Sebastien Egger, Matthias Keller, Peter M. Antimicrob Agents Chemother Susceptibility Mutations in the genes of the F(420) signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC. American Society for Microbiology 2020-10-20 /pmc/articles/PMC7577131/ /pubmed/32868333 http://dx.doi.org/10.1128/AAC.00513-20 Text en Copyright © 2020 Reichmuth et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Susceptibility Reichmuth, Martina L. Hömke, Rico Zürcher, Kathrin Sander, Peter Avihingsanon, Anchalee Collantes, Jimena Loiseau, Chloé Borrell, Sonia Reinhard, Miriam Wilkinson, Robert J. Yotebieng, Marcel Fenner, Lukas Böttger, Erik C. Gagneux, Sebastien Egger, Matthias Keller, Peter M. Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title | Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title_full | Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title_fullStr | Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title_full_unstemmed | Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title_short | Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients |
| title_sort | natural polymorphisms in mycobacterium tuberculosis conferring resistance to delamanid in drug-naive patients |
| topic | Susceptibility |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577131/ https://www.ncbi.nlm.nih.gov/pubmed/32868333 http://dx.doi.org/10.1128/AAC.00513-20 |
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