Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model

Activities of cefiderocol under simulated human plasma concentrations at the recommended dosing regimen of 2 g every 8 h with a 3-h infusion were evaluated using an in vitro chemostat model. Against a total of 6 meropenem-resistant Gram-negative strains with cefiderocol MICs of 0.5 to 4 μg/ml, inclu...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Shuhei, Kanazawa, Sachi, Sato, Takafumi, Yamano, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577172/
https://www.ncbi.nlm.nih.gov/pubmed/32900685
http://dx.doi.org/10.1128/AAC.01128-20
_version_ 1783598149075468288
author Matsumoto, Shuhei
Kanazawa, Sachi
Sato, Takafumi
Yamano, Yoshinori
author_facet Matsumoto, Shuhei
Kanazawa, Sachi
Sato, Takafumi
Yamano, Yoshinori
author_sort Matsumoto, Shuhei
collection PubMed
description Activities of cefiderocol under simulated human plasma concentrations at the recommended dosing regimen of 2 g every 8 h with a 3-h infusion were evaluated using an in vitro chemostat model. Against a total of 6 meropenem-resistant Gram-negative strains with cefiderocol MICs of 0.5 to 4 μg/ml, including metallo-β-lactamase producers and carbapenem-resistant Acinetobacter baumannii, cefiderocol treatment showed a bactericidal effect within 8 h and sustained efficacy with no marked bacterial regrowth over 24 h.
format Online
Article
Text
id pubmed-7577172
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-75771722020-10-30 Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model Matsumoto, Shuhei Kanazawa, Sachi Sato, Takafumi Yamano, Yoshinori Antimicrob Agents Chemother Pharmacology Activities of cefiderocol under simulated human plasma concentrations at the recommended dosing regimen of 2 g every 8 h with a 3-h infusion were evaluated using an in vitro chemostat model. Against a total of 6 meropenem-resistant Gram-negative strains with cefiderocol MICs of 0.5 to 4 μg/ml, including metallo-β-lactamase producers and carbapenem-resistant Acinetobacter baumannii, cefiderocol treatment showed a bactericidal effect within 8 h and sustained efficacy with no marked bacterial regrowth over 24 h. American Society for Microbiology 2020-10-20 /pmc/articles/PMC7577172/ /pubmed/32900685 http://dx.doi.org/10.1128/AAC.01128-20 Text en Copyright © 2020 Matsumoto et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Pharmacology
Matsumoto, Shuhei
Kanazawa, Sachi
Sato, Takafumi
Yamano, Yoshinori
Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title_full Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title_fullStr Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title_full_unstemmed Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title_short Activities of Cefiderocol with Simulated Human Plasma Concentrations against Carbapenem-Resistant Gram-Negative Bacilli in an In Vitro Chemostat Model
title_sort activities of cefiderocol with simulated human plasma concentrations against carbapenem-resistant gram-negative bacilli in an in vitro chemostat model
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577172/
https://www.ncbi.nlm.nih.gov/pubmed/32900685
http://dx.doi.org/10.1128/AAC.01128-20
work_keys_str_mv AT matsumotoshuhei activitiesofcefiderocolwithsimulatedhumanplasmaconcentrationsagainstcarbapenemresistantgramnegativebacilliinaninvitrochemostatmodel
AT kanazawasachi activitiesofcefiderocolwithsimulatedhumanplasmaconcentrationsagainstcarbapenemresistantgramnegativebacilliinaninvitrochemostatmodel
AT satotakafumi activitiesofcefiderocolwithsimulatedhumanplasmaconcentrationsagainstcarbapenemresistantgramnegativebacilliinaninvitrochemostatmodel
AT yamanoyoshinori activitiesofcefiderocolwithsimulatedhumanplasmaconcentrationsagainstcarbapenemresistantgramnegativebacilliinaninvitrochemostatmodel

Ejemplares similares