Cargando…

Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study

IMPORTANCE: Observational studies highlight associations of C-reactive protein (CRP), a general marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP production, with individual depressive symptoms. However, it is unclear whether inflammatory activity is associated with indivi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kappelmann, Nils, Arloth, Janine, Georgakis, Marios K., Czamara, Darina, Rost, Nicolas, Ligthart, Symen, Khandaker, Golam M., Binder, Elisabeth B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2020
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577200/ https://www.ncbi.nlm.nih.gov/pubmed/33079133 http://dx.doi.org/10.1001/jamapsychiatry.2020.3436

Ejemplares similares

Associations of Immunological Proteins/Traits with Schizophrenia, Major Depression and Bipolar Disorder: A Bi-Directional Two-Sample Mendelian Randomization Study
por: Perry, Benjamin I., et al.
Publicado: (2021)

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
por: Czamara, Darina, et al.
Publicado: (2022)

Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study
por: Khandaker, Golam M., et al.
Publicado: (2018)

Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19
por: Kappelmann, Nils, et al.
Publicado: (2021)

Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms
por: Foley, Éimear M., et al.
Publicado: (2021)

“DNA Methylation signatures in panic disorder”
por: Iurato, Stella, et al.
Publicado: (2017)

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
por: Wiechmann, Tobias, et al.
Publicado: (2019)

Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study
por: Williams, John A., et al.
Publicado: (2022)

Commentary: CRP and schizophrenia: cause, consequence or confounding?
por: Ligthart, Symen
Publicado: (2019)

Role of inflammation in depression and anxiety: Tests for disorder specificity, linearity and potential causality of association in the UK Biobank
por: Ye, Zheng, et al.
Publicado: (2021)

Genetically Determined Platelet Count and Risk of Cardiovascular Disease: Mendelian Randomization Study
por: Gill, Dipender, et al.
Publicado: (2018)

Systemic inflammation and intelligence in early adulthood and subsequent risk of schizophrenia and other non-affective psychoses: a longitudinal cohort and co-relative study
por: Kappelmann, Nils, et al.
Publicado: (2019)

Smoking and heart failure: a Mendelian randomization and mediation analysis
por: Lu, Yunlong, et al.
Publicado: (2021)

Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis
por: Harshfield, Eric L., et al.
Publicado: (2021)

Vitamin D and C-Reactive Protein: A Mendelian Randomization Study
por: Liefaard, Marte C., et al.
Publicado: (2015)

Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study
por: Fani, Lana, et al.
Publicado: (2021)

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders
por: Suarez, Anna, et al.
Publicado: (2020)

Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study
por: Hartwig, Fernando Pires, et al.
Publicado: (2017)

The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study
por: Perry, Benjamin I., et al.
Publicado: (2021)

16.4 EFFECT OF GENOTYPE AND EARLY ADVERSITY ENVIRONMENT ON DNA METHYLATION
por: Czamara, Darina, et al.
Publicado: (2018)

Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis
por: Georgakis, Marios K., et al.
Publicado: (2021)

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study
por: Frerich, Simon, et al.
Publicado: (2021)

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis
por: Gill, Dipender, et al.
Publicado: (2020)

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts
por: Milaneschi, Yuri, et al.
Publicado: (2021)

Correction: Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts
por: Milaneschi, Yuri, et al.
Publicado: (2021)

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study
por: Georgakis, Marios K., et al.
Publicado: (2020)

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study
por: Georgakis, Marios K., et al.
Publicado: (2021)

Stress-induced brain responses are associated with BMI in women
por: Kühnel, Anne, et al.
Publicado: (2023)

Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study
por: Saadullah Khani, Noushin, et al.
Publicado: (2023)

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk: A 2-Sample Mendelian Randomization Study
por: Sood, Tushar, et al.
Publicado: (2023)

Assessment of the Role of IQ in Associations Between Population Density and Deprivation and Nonaffective Psychosis
por: Lewis, Gemma, et al.
Publicado: (2020)

Downregulation of interleukin 6 signaling might reduce the risk of periodontitis: a drug target Mendelian randomization study
por: Nolde, Michael, et al.
Publicado: (2023)

Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case
por: Reisser, Cyrielle, et al.
Publicado: (2013)

Stable longitudinal associations of family income with children’s hippocampal volume and memory persist after controlling for polygenic scores of educational attainment
por: Raffington, Laurel, et al.
Publicado: (2019)

Non-Mendelian Dominant Maternal Effects Caused by CRISPR/Cas9 Transgenic Components in Drosophila melanogaster
por: Lin, Chun-Chieh, et al.
Publicado: (2016)

Developmental Ethanol Exposure Leads to Dysregulation of Lipid Metabolism and Oxidative Stress in Drosophila
por: Logan-Garbisch, Theresa, et al.
Publicado: (2014)

Quantitative Genomic Dissection of Soybean Yield Components
por: Xavier, Alencar, et al.
Publicado: (2019)

Stress dynamically regulates co-expression networks of glucocorticoid receptor-dependent MDD and SCZ risk genes
por: Zimmermann, Christoph A., et al.
Publicado: (2019)

Commentary: Causal associations between inflammation, cardiometabolic markers and schizophrenia: the known unknowns
por: Khandaker, Golam M
Publicado: (2019)

Genetic Dissection of a QTL Affecting Bone Geometry
por: Sabik, Olivia L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j9gbn4ijtn281emdb89bea33e4