On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s safety and the efficiency may be affected by the pre...

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Detalles Bibliográficos
Autores principales: Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Tang, Peifeng, Hoffman, Laurel, Kuang, June, Liu, Peiran, Huang, Chao, Du, Cheng, Tao, Li, Chemmalil, Letha, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577237/
https://www.ncbi.nlm.nih.gov/pubmed/33016217
http://dx.doi.org/10.1080/19420862.2020.1829333

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