A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV

The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this novel pneumonia. This paper provides a potential treatment for COVID-19 utilizing resonance to destroy the infection ability of 2019-nCoV. Firstly, the geometry size of 2019-nCoV is sca...

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Autores principales: Yao, Minghui, Wang, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577368/
https://www.ncbi.nlm.nih.gov/pubmed/33106729
http://dx.doi.org/10.1007/s11071-020-06019-1
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author Yao, Minghui
Wang, Hongbo
author_facet Yao, Minghui
Wang, Hongbo
author_sort Yao, Minghui
collection PubMed
description The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this novel pneumonia. This paper provides a potential treatment for COVID-19 utilizing resonance to destroy the infection ability of 2019-nCoV. Firstly, the geometry size of 2019-nCoV is scaled up by 10,000 times. The additional mass is used to represent the effect of the fluid around a spike protein. The finite element analysis (FEA) is used to study the modal characteristics of the tuned 2019-nCoV model and mistuned 2019-nCoV model in blood, respectively. Based on FEA, the lumped parameter mechanical model of 2019-nCoV is established. Then, the dynamic responses of mistuned 2019-nCoV are investigated through harmonic response and dynamical analysis. Finally, a potential method utilizing 360° sweep excitation to cure COVID-19 is put forward.
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spelling pubmed-75773682020-10-22 A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV Yao, Minghui Wang, Hongbo Nonlinear Dyn Original Paper The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this novel pneumonia. This paper provides a potential treatment for COVID-19 utilizing resonance to destroy the infection ability of 2019-nCoV. Firstly, the geometry size of 2019-nCoV is scaled up by 10,000 times. The additional mass is used to represent the effect of the fluid around a spike protein. The finite element analysis (FEA) is used to study the modal characteristics of the tuned 2019-nCoV model and mistuned 2019-nCoV model in blood, respectively. Based on FEA, the lumped parameter mechanical model of 2019-nCoV is established. Then, the dynamic responses of mistuned 2019-nCoV are investigated through harmonic response and dynamical analysis. Finally, a potential method utilizing 360° sweep excitation to cure COVID-19 is put forward. Springer Netherlands 2020-10-21 2021 /pmc/articles/PMC7577368/ /pubmed/33106729 http://dx.doi.org/10.1007/s11071-020-06019-1 Text en © Springer Nature B.V. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Yao, Minghui
Wang, Hongbo
A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title_full A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title_fullStr A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title_full_unstemmed A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title_short A potential treatment for COVID-19 based on modal characteristics and dynamic responses analysis of 2019-nCoV
title_sort potential treatment for covid-19 based on modal characteristics and dynamic responses analysis of 2019-ncov
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577368/
https://www.ncbi.nlm.nih.gov/pubmed/33106729
http://dx.doi.org/10.1007/s11071-020-06019-1
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