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Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma

BACKGROUND: We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C. METHODS: We retrospectively analyzed 604 patients with HCC diagno...

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Autores principales: Bekki, Shigemune, Hashimoto, Satoru, Yamasaki, Kazumi, Komori, Atsumasa, Abiru, Seigo, Nagaoka, Shinya, Saeki, Akira, Suehiro, Tomoyuki, Kugiyama, Yuki, Beppu, Asami, Kuroki, Tamotsu, Nakamura, Minoru, Ito, Masahiro, Yatsuhashi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577466/
https://www.ncbi.nlm.nih.gov/pubmed/33085694
http://dx.doi.org/10.1371/journal.pone.0241002
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author Bekki, Shigemune
Hashimoto, Satoru
Yamasaki, Kazumi
Komori, Atsumasa
Abiru, Seigo
Nagaoka, Shinya
Saeki, Akira
Suehiro, Tomoyuki
Kugiyama, Yuki
Beppu, Asami
Kuroki, Tamotsu
Nakamura, Minoru
Ito, Masahiro
Yatsuhashi, Hiroshi
author_facet Bekki, Shigemune
Hashimoto, Satoru
Yamasaki, Kazumi
Komori, Atsumasa
Abiru, Seigo
Nagaoka, Shinya
Saeki, Akira
Suehiro, Tomoyuki
Kugiyama, Yuki
Beppu, Asami
Kuroki, Tamotsu
Nakamura, Minoru
Ito, Masahiro
Yatsuhashi, Hiroshi
author_sort Bekki, Shigemune
collection PubMed
description BACKGROUND: We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C. METHODS: We retrospectively analyzed 604 patients with HCC diagnosed between January 1999 and December 2015, and 288 patients without HCC who were seen at the National Hospital Organization Nagasaki Medical Center between October 2014 and November 2017. The association between serum kynurenine and prognosis was evaluated using the Cox’s proportional hazards regression analysis. RESULTS: Patients with HCC had significantly higher values of serum kynurenine than patients without HCC (median: 557.1 vs. 464.2 ng/mL, p<0.001). Five-year survival rates of HCC patients with serum kynurenine ≥900 (n = 65), 600–899 (n = 194), and <600 ng/mL (n = 345) were 30.6%, 47.4%, and 61.4%, respectively (p = 0.001, log-rank test). Multivariate analysis identified serum kynurenine as an independent predictor for prognosis of HCC patients. The hazard ratio of serum kynurenine ≥900, and 600–899 compared with serum kynurenine <600 ng/mL were 1.91 (p<0.001) and 1.37 (p = 0.015), respectively. CONCLUSIONS: A high level of serum kynurenine correlated with poor prognosis of HCC. Serum kynurenine levels may be a novel biomarker to predict the prognosis of patients with HCC. The development of drugs that inhibit kynurenine production is expected to help improve the prognosis of patients with HCC.
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spelling pubmed-75774662020-10-26 Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma Bekki, Shigemune Hashimoto, Satoru Yamasaki, Kazumi Komori, Atsumasa Abiru, Seigo Nagaoka, Shinya Saeki, Akira Suehiro, Tomoyuki Kugiyama, Yuki Beppu, Asami Kuroki, Tamotsu Nakamura, Minoru Ito, Masahiro Yatsuhashi, Hiroshi PLoS One Research Article BACKGROUND: We examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C. METHODS: We retrospectively analyzed 604 patients with HCC diagnosed between January 1999 and December 2015, and 288 patients without HCC who were seen at the National Hospital Organization Nagasaki Medical Center between October 2014 and November 2017. The association between serum kynurenine and prognosis was evaluated using the Cox’s proportional hazards regression analysis. RESULTS: Patients with HCC had significantly higher values of serum kynurenine than patients without HCC (median: 557.1 vs. 464.2 ng/mL, p<0.001). Five-year survival rates of HCC patients with serum kynurenine ≥900 (n = 65), 600–899 (n = 194), and <600 ng/mL (n = 345) were 30.6%, 47.4%, and 61.4%, respectively (p = 0.001, log-rank test). Multivariate analysis identified serum kynurenine as an independent predictor for prognosis of HCC patients. The hazard ratio of serum kynurenine ≥900, and 600–899 compared with serum kynurenine <600 ng/mL were 1.91 (p<0.001) and 1.37 (p = 0.015), respectively. CONCLUSIONS: A high level of serum kynurenine correlated with poor prognosis of HCC. Serum kynurenine levels may be a novel biomarker to predict the prognosis of patients with HCC. The development of drugs that inhibit kynurenine production is expected to help improve the prognosis of patients with HCC. Public Library of Science 2020-10-21 /pmc/articles/PMC7577466/ /pubmed/33085694 http://dx.doi.org/10.1371/journal.pone.0241002 Text en © 2020 Bekki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bekki, Shigemune
Hashimoto, Satoru
Yamasaki, Kazumi
Komori, Atsumasa
Abiru, Seigo
Nagaoka, Shinya
Saeki, Akira
Suehiro, Tomoyuki
Kugiyama, Yuki
Beppu, Asami
Kuroki, Tamotsu
Nakamura, Minoru
Ito, Masahiro
Yatsuhashi, Hiroshi
Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title_full Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title_fullStr Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title_full_unstemmed Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title_short Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
title_sort serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577466/
https://www.ncbi.nlm.nih.gov/pubmed/33085694
http://dx.doi.org/10.1371/journal.pone.0241002
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