Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines

The aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of...

Descripción completa

Detalles Bibliográficos
Autores principales: Parsonidis, Panagiotis, Vlachou, Ioanna, Mamagkaki, Alexandra, Bouris, Ioannis, Daikopoulou, Vasiliki, Papasotiriou, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577469/
https://www.ncbi.nlm.nih.gov/pubmed/33085705
http://dx.doi.org/10.1371/journal.pone.0240969
_version_ 1783598196485783552
author Parsonidis, Panagiotis
Vlachou, Ioanna
Mamagkaki, Alexandra
Bouris, Ioannis
Daikopoulou, Vasiliki
Papasotiriou, Ioannis
author_facet Parsonidis, Panagiotis
Vlachou, Ioanna
Mamagkaki, Alexandra
Bouris, Ioannis
Daikopoulou, Vasiliki
Papasotiriou, Ioannis
author_sort Parsonidis, Panagiotis
collection PubMed
description The aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of dissolution, disintegration, HPLC, LC/MS, GC/MS and NMR. Cytotoxicity was assessed by MTT, SRB, CVE colorimetric viability assays in 0, 24, 48 and 72h time points. The results indicate that Tegaran Formula ZhenHua supplement did not present any cytotoxic effects due to issues related to the capsules’ solubility, distribution and identification of the active ingredient.
format Online
Article
Text
id pubmed-7577469
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-75774692020-10-26 Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines Parsonidis, Panagiotis Vlachou, Ioanna Mamagkaki, Alexandra Bouris, Ioannis Daikopoulou, Vasiliki Papasotiriou, Ioannis PLoS One Research Article The aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of dissolution, disintegration, HPLC, LC/MS, GC/MS and NMR. Cytotoxicity was assessed by MTT, SRB, CVE colorimetric viability assays in 0, 24, 48 and 72h time points. The results indicate that Tegaran Formula ZhenHua supplement did not present any cytotoxic effects due to issues related to the capsules’ solubility, distribution and identification of the active ingredient. Public Library of Science 2020-10-21 /pmc/articles/PMC7577469/ /pubmed/33085705 http://dx.doi.org/10.1371/journal.pone.0240969 Text en © 2020 Parsonidis et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Parsonidis, Panagiotis
Vlachou, Ioanna
Mamagkaki, Alexandra
Bouris, Ioannis
Daikopoulou, Vasiliki
Papasotiriou, Ioannis
Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title_full Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title_fullStr Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title_full_unstemmed Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title_short Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines
title_sort evaluation of tegaran formula zhenhua cytotoxicity against human cancer cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577469/
https://www.ncbi.nlm.nih.gov/pubmed/33085705
http://dx.doi.org/10.1371/journal.pone.0240969
work_keys_str_mv AT parsonidispanagiotis evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT vlachouioanna evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT mamagkakialexandra evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT bourisioannis evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT daikopoulouvasiliki evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT papasotiriouioannis evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines

Ejemplares similares