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A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic

As the number of cases of COVID-19 continues to grow, local health services are at risk of being overwhelmed with patients requiring intensive care. We develop and implement an algorithm to provide optimal re-routing strategies to either transfer patients requiring Intensive Care Units (ICU) or vent...

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Detalles Bibliográficos
Autores principales: Lacasa, Lucas, Challen, Robert, Brooks-Pollock, Ellen, Danon, Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577502/
https://www.ncbi.nlm.nih.gov/pubmed/33085729
http://dx.doi.org/10.1371/journal.pone.0241027
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author Lacasa, Lucas
Challen, Robert
Brooks-Pollock, Ellen
Danon, Leon
author_facet Lacasa, Lucas
Challen, Robert
Brooks-Pollock, Ellen
Danon, Leon
author_sort Lacasa, Lucas
collection PubMed
description As the number of cases of COVID-19 continues to grow, local health services are at risk of being overwhelmed with patients requiring intensive care. We develop and implement an algorithm to provide optimal re-routing strategies to either transfer patients requiring Intensive Care Units (ICU) or ventilators, constrained by feasibility of transfer. We validate our approach with realistic data from the United Kingdom and Spain. In the UK, we consider the National Health Service at the level of trusts and define a 4-regular geometric graph which indicates the four nearest neighbours of any given trust. In Spain we coarse-grain the healthcare system at the level of autonomous communities, and extract similar contact networks. Through random search optimisation we identify the best load sharing strategy, where the cost function to minimise is based on the total number of ICU units above capacity. Our framework is general and flexible allowing for additional criteria, alternative cost functions, and can be extended to other resources beyond ICU units or ventilators. Assuming a uniform ICU demand, we show that it is possible to enable access to ICU for up to 1000 additional cases in the UK in a single step of the algorithm. Under a more realistic and heterogeneous demand, our method is able to balance about 600 beds per step in the Spanish system only using local sharing, and over 1300 using countrywide sharing, potentially saving a large percentage of these lives that would otherwise not have access to ICU.
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spelling pubmed-75775022020-10-26 A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic Lacasa, Lucas Challen, Robert Brooks-Pollock, Ellen Danon, Leon PLoS One Research Article As the number of cases of COVID-19 continues to grow, local health services are at risk of being overwhelmed with patients requiring intensive care. We develop and implement an algorithm to provide optimal re-routing strategies to either transfer patients requiring Intensive Care Units (ICU) or ventilators, constrained by feasibility of transfer. We validate our approach with realistic data from the United Kingdom and Spain. In the UK, we consider the National Health Service at the level of trusts and define a 4-regular geometric graph which indicates the four nearest neighbours of any given trust. In Spain we coarse-grain the healthcare system at the level of autonomous communities, and extract similar contact networks. Through random search optimisation we identify the best load sharing strategy, where the cost function to minimise is based on the total number of ICU units above capacity. Our framework is general and flexible allowing for additional criteria, alternative cost functions, and can be extended to other resources beyond ICU units or ventilators. Assuming a uniform ICU demand, we show that it is possible to enable access to ICU for up to 1000 additional cases in the UK in a single step of the algorithm. Under a more realistic and heterogeneous demand, our method is able to balance about 600 beds per step in the Spanish system only using local sharing, and over 1300 using countrywide sharing, potentially saving a large percentage of these lives that would otherwise not have access to ICU. Public Library of Science 2020-10-21 /pmc/articles/PMC7577502/ /pubmed/33085729 http://dx.doi.org/10.1371/journal.pone.0241027 Text en © 2020 Lacasa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lacasa, Lucas
Challen, Robert
Brooks-Pollock, Ellen
Danon, Leon
A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title_full A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title_fullStr A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title_full_unstemmed A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title_short A flexible method for optimising sharing of healthcare resources and demand in the context of the COVID-19 pandemic
title_sort flexible method for optimising sharing of healthcare resources and demand in the context of the covid-19 pandemic
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577502/
https://www.ncbi.nlm.nih.gov/pubmed/33085729
http://dx.doi.org/10.1371/journal.pone.0241027
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