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Paraneoplastic anti-NMDA receptor encephalitis in 1830?

OBJECTIVE: Our aim was to identify patients with probable anti-NMDA receptor encephalitis among historical medical cases. METHOD: A case report published in leading Hungarian-, German- and Italian-language medical journals in the early 1840s was revisited. RESULTS: In 1830, an 18-year-old, healthy w...

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Autores principales: Tényi, Dalma, Szűcs, Anna, Kovács, Norbert, Illés, Zsolt, Janszky, József
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577529/
https://www.ncbi.nlm.nih.gov/pubmed/32978290
http://dx.doi.org/10.1212/NXI.0000000000000887
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author Tényi, Dalma
Szűcs, Anna
Kovács, Norbert
Illés, Zsolt
Janszky, József
author_facet Tényi, Dalma
Szűcs, Anna
Kovács, Norbert
Illés, Zsolt
Janszky, József
author_sort Tényi, Dalma
collection PubMed
description OBJECTIVE: Our aim was to identify patients with probable anti-NMDA receptor encephalitis among historical medical cases. METHOD: A case report published in leading Hungarian-, German- and Italian-language medical journals in the early 1840s was revisited. RESULTS: In 1830, an 18-year-old, healthy woman suffered epileptic seizures, followed by a 6-day-long state characterized by catalepsy, unresponsiveness, motionless, and light breathing. Her symptoms regularly returned in the following 1.5 years. Meanwhile, a progressively growing huge abdominal tumor appeared. One day, she suddenly started vomiting a large amount of foul-smelling pus mixed with blood, accompanied by bone fragments. Pus mixed blood with some membranous substance was also evacuated through the anus and vagina. After this event, she completely recovered; 1.5 years later, she married and later gave birth to 3 healthy children. The patient remained healthy during the 11-year follow-up. CONCLUSIONS: We suggest that in the description of a paraneoplastic case, an anti-NMDA receptor encephalitis can be dated back as far as to the 19th century, with an especially rare type of resolution: the disappearance of the symptoms after the spontaneous elimination of an ovarian teratoma.
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spelling pubmed-75775292020-10-30 Paraneoplastic anti-NMDA receptor encephalitis in 1830? Tényi, Dalma Szűcs, Anna Kovács, Norbert Illés, Zsolt Janszky, József Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: Our aim was to identify patients with probable anti-NMDA receptor encephalitis among historical medical cases. METHOD: A case report published in leading Hungarian-, German- and Italian-language medical journals in the early 1840s was revisited. RESULTS: In 1830, an 18-year-old, healthy woman suffered epileptic seizures, followed by a 6-day-long state characterized by catalepsy, unresponsiveness, motionless, and light breathing. Her symptoms regularly returned in the following 1.5 years. Meanwhile, a progressively growing huge abdominal tumor appeared. One day, she suddenly started vomiting a large amount of foul-smelling pus mixed with blood, accompanied by bone fragments. Pus mixed blood with some membranous substance was also evacuated through the anus and vagina. After this event, she completely recovered; 1.5 years later, she married and later gave birth to 3 healthy children. The patient remained healthy during the 11-year follow-up. CONCLUSIONS: We suggest that in the description of a paraneoplastic case, an anti-NMDA receptor encephalitis can be dated back as far as to the 19th century, with an especially rare type of resolution: the disappearance of the symptoms after the spontaneous elimination of an ovarian teratoma. Lippincott Williams & Wilkins 2020-09-25 /pmc/articles/PMC7577529/ /pubmed/32978290 http://dx.doi.org/10.1212/NXI.0000000000000887 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Tényi, Dalma
Szűcs, Anna
Kovács, Norbert
Illés, Zsolt
Janszky, József
Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title_full Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title_fullStr Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title_full_unstemmed Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title_short Paraneoplastic anti-NMDA receptor encephalitis in 1830?
title_sort paraneoplastic anti-nmda receptor encephalitis in 1830?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577529/
https://www.ncbi.nlm.nih.gov/pubmed/32978290
http://dx.doi.org/10.1212/NXI.0000000000000887
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