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Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV

OBJECTIVE: To determine whether oxidative stress in virologically suppressed people with HIV (PWH) may contribute to or result from neurodegeneration, we measured 7,8-dihydro-8-oxoguanine (8-oxo-dG), a marker of DNA damage due to oxidative stress, and markers of age-related neurodegeneration, specif...

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Detalles Bibliográficos
Autores principales:	Ellis, Ronald J., Moore, David J., Sundermann, Erin E., Heaton, Robert K., Mehta, Sanjay, Hulgan, Todd, Samuels, David, Fields, Jerel A., Letendre, Scott L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577534/ https://www.ncbi.nlm.nih.gov/pubmed/33055205 http://dx.doi.org/10.1212/NXI.0000000000000902

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