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Brain-homing CD4(+) T cells display glucocorticoid-resistant features in MS

OBJECTIVE: To study whether glucocorticoid (GC) resistance delineates disease-relevant T helper (Th) subsets that home to the CNS of patients with early MS. METHODS: The expression of key determinants of GC sensitivity, multidrug resistance protein 1 (MDR1/ABCB1) and glucocorticoid receptor (GR/NR3C...

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Detalles Bibliográficos
Autores principales:	Koetzier, Steven C., van Langelaar, Jamie, Blok, Katelijn M., van den Bosch, Thierry P.P., Wierenga-Wolf, Annet F., Melief, Marie-José, Pol, Kim, Siepman, Theodora A., Verjans, Georges M.G.M., Smolders, Joost, Lubberts, Erik, de Vries, Helga E., van Luijn, Marvin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577536/ https://www.ncbi.nlm.nih.gov/pubmed/33037101 http://dx.doi.org/10.1212/NXI.0000000000000894

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