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The structural basis for Z α(1)-antitrypsin polymerization in the liver

The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α(1)-Antitrypsin deficiency is the archetypal serpinopathy and results from the formation and deposition of mutant forms of α(1)-antitrypsin as “polym...

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Detalles Bibliográficos
Autores principales:	Faull, Sarah V., Elliston, Emma L. K., Gooptu, Bibek, Jagger, Alistair M., Aldobiyan, Ibrahim, Redzej, Adam, Badaoui, Magd, Heyer-Chauhan, Nina, Rashid, S. Tamir, Reynolds, Gary M., Adams, David H., Miranda, Elena, Orlova, Elena V., Irving, James A., Lomas, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577719/ https://www.ncbi.nlm.nih.gov/pubmed/33087346 http://dx.doi.org/10.1126/sciadv.abc1370

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