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Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana

The “mismatch” between evolved human physiology and Western lifestyles is thought to explain the current epidemic of cardiovascular disease (CVD) in industrialized societies. However, this hypothesis has been difficult to test because few populations concurrently span ancestral and modern lifestyles...

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Detalles Bibliográficos
Autores principales: Lea, Amanda J., Martins, Dino, Kamau, Joseph, Gurven, Michael, Ayroles, Julien F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577730/
https://www.ncbi.nlm.nih.gov/pubmed/33087362
http://dx.doi.org/10.1126/sciadv.abb1430
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author Lea, Amanda J.
Martins, Dino
Kamau, Joseph
Gurven, Michael
Ayroles, Julien F.
author_facet Lea, Amanda J.
Martins, Dino
Kamau, Joseph
Gurven, Michael
Ayroles, Julien F.
author_sort Lea, Amanda J.
collection PubMed
description The “mismatch” between evolved human physiology and Western lifestyles is thought to explain the current epidemic of cardiovascular disease (CVD) in industrialized societies. However, this hypothesis has been difficult to test because few populations concurrently span ancestral and modern lifestyles. To address this gap, we collected interview and biomarker data from individuals of Turkana ancestry who practice subsistence-level, nomadic pastoralism (the ancestral way of life for this group), as well as individuals who no longer practice pastoralism and live in urban areas. We found that Turkana who move to cities exhibit poor cardiometabolic health, partially because of a shift toward “Western diets” high in refined carbohydrates. We also show that being born in an urban area independently predicts adult health, such that life-long city dwellers will experience the greatest CVD risk. By focusing on a substantial lifestyle gradient, our work thus informs the timing, magnitude, and evolutionary causes of CVD.
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spelling pubmed-75777302020-11-02 Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana Lea, Amanda J. Martins, Dino Kamau, Joseph Gurven, Michael Ayroles, Julien F. Sci Adv Research Articles The “mismatch” between evolved human physiology and Western lifestyles is thought to explain the current epidemic of cardiovascular disease (CVD) in industrialized societies. However, this hypothesis has been difficult to test because few populations concurrently span ancestral and modern lifestyles. To address this gap, we collected interview and biomarker data from individuals of Turkana ancestry who practice subsistence-level, nomadic pastoralism (the ancestral way of life for this group), as well as individuals who no longer practice pastoralism and live in urban areas. We found that Turkana who move to cities exhibit poor cardiometabolic health, partially because of a shift toward “Western diets” high in refined carbohydrates. We also show that being born in an urban area independently predicts adult health, such that life-long city dwellers will experience the greatest CVD risk. By focusing on a substantial lifestyle gradient, our work thus informs the timing, magnitude, and evolutionary causes of CVD. American Association for the Advancement of Science 2020-10-21 /pmc/articles/PMC7577730/ /pubmed/33087362 http://dx.doi.org/10.1126/sciadv.abb1430 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Lea, Amanda J.
Martins, Dino
Kamau, Joseph
Gurven, Michael
Ayroles, Julien F.
Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title_full Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title_fullStr Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title_full_unstemmed Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title_short Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana
title_sort urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the turkana
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577730/
https://www.ncbi.nlm.nih.gov/pubmed/33087362
http://dx.doi.org/10.1126/sciadv.abb1430
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