Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids

Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress in single-cell RNA sequencing (scRNA-seq) technologies enables identification of cell-type-specific pathophysiology. However, its a...

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Detalles Bibliográficos
Autores principales: Sawada, Tomoyo, Chater, Thomas E., Sasagawa, Yohei, Yoshimura, Mika, Fujimori-Tonou, Noriko, Tanaka, Kaori, Benjamin, Kynon J. M., Paquola, Apuã C. M., Erwin, Jennifer A., Goda, Yukiko, Nikaido, Itoshi, Kato, Tadafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577852/
https://www.ncbi.nlm.nih.gov/pubmed/32764691
http://dx.doi.org/10.1038/s41380-020-0844-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577852/
https://www.ncbi.nlm.nih.gov/pubmed/32764691
http://dx.doi.org/10.1038/s41380-020-0844-z

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