Cargando…

Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids

Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress in single-cell RNA sequencing (scRNA-seq) technologies enables identification of cell-type-specific pathophysiology. However, its a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sawada, Tomoyo, Chater, Thomas E., Sasagawa, Yohei, Yoshimura, Mika, Fujimori-Tonou, Noriko, Tanaka, Kaori, Benjamin, Kynon J. M., Paquola, Apuã C. M., Erwin, Jennifer A., Goda, Yukiko, Nikaido, Itoshi, Kato, Tadafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Immediate Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577852/ https://www.ncbi.nlm.nih.gov/pubmed/32764691 http://dx.doi.org/10.1038/s41380-020-0844-z

Ejemplares similares

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
por: Samudyata, et al.
Publicado: (2022)

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids
por: Notaras, Michael, et al.
Publicado: (2021)

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
por: Yamamoto, Hirona, et al.
Publicado: (2023)

dRFEtools: dynamic recursive feature elimination for omics
por: Benjamin, Kynon J M, et al.
Publicado: (2023)

Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium
por: Sawada, Tomoyo, et al.
Publicado: (2020)

Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations
por: Kataoka, M, et al.
Publicado: (2016)

Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus
por: Kasahara, T, et al.
Publicado: (2016)

Visual analysis of geocoded twin data puts nature and nurture on the map
por: Davis, O S P, et al.
Publicado: (2012)

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
por: Ayalew, M, et al.
Publicado: (2012)

Corticotropin-releasing hormone exerts direct effects on neuronal progenitor cells: implications for neuroprotection
por: Koutmani, Y, et al.
Publicado: (2013)

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
por: Kirov, G, et al.
Publicado: (2012)

Discovery and validation of blood biomarkers for suicidality
por: Le-Niculescu, H, et al.
Publicado: (2013)

Evidence that duplications of 22q11.2 protect against schizophrenia
por: Rees, E, et al.
Publicado: (2014)

Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia
por: Weickert, T W, et al.
Publicado: (2015)

Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease
por: Lalli, M A, et al.
Publicado: (2015)

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
por: Niculescu, A B, et al.
Publicado: (2015)

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
por: Davies, G, et al.
Publicado: (2016)

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
por: Smith, D J, et al.
Publicado: (2016)

Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η
por: Workman, E R, et al.
Publicado: (2015)

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
por: Davies, G, et al.
Publicado: (2015)

Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin
por: Rossier, J, et al.
Publicado: (2015)

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic
por: Lencz, T, et al.
Publicado: (2015)

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin
por: Tan, Z, et al.
Publicado: (2015)

Schizophrenia copy number variants and associative learning
por: Clifton, N E, et al.
Publicado: (2017)

Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors
por: Sellgren, C M, et al.
Publicado: (2017)

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ
por: Knight, E M, et al.
Publicado: (2015)

Reduced pCREB in Alzheimer's disease prefrontal cortex is reflected in peripheral blood mononuclear cells
por: Bartolotti, N, et al.
Publicado: (2016)

Methamphetamine abuse impairs motor cortical plasticity and function
por: Huang, X, et al.
Publicado: (2017)

Precision medicine for suicidality: from universality to subtypes and personalization
por: Niculescu, A B, et al.
Publicado: (2017)

Meta-analysis of epigenome-wide association studies of cognitive abilities
por: Marioni, Riccardo E., et al.
Publicado: (2018)

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
por: Clarke, T-K, et al.
Publicado: (2017)

DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders
por: Ryan, Niamh M., et al.
Publicado: (2018)

The hippocampal extracellular matrix regulates pain and memory after injury
por: Tajerian, Maral, et al.
Publicado: (2018)

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
por: Soto, Marion, et al.
Publicado: (2018)

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
por: Hill, W. D., et al.
Publicado: (2018)

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
por: Long, Justin M., et al.
Publicado: (2018)

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
por: Trampush, J W, et al.
Publicado: (2017)

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences
por: Thorgeirsson, T E, et al.
Publicado: (2016)

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs
por: Niculescu, A. B., et al.
Publicado: (2019)

Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment
por: Genaro-Mattos, Thiago C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4ov4603nu20pg27akm1v9l79ba