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Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schizophrenia. We tested the extent to which: (1) brain KP enzyme mRNAs, (2) brain KP metabolit...

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Detalles Bibliográficos
Autores principales:	Kindler, Jochen, Lim, Chai K., Weickert, Cynthia Shannon, Boerrigter, Danny, Galletly, Cherrie, Liu, Dennis, Jacobs, Kelly R., Balzan, Ryan, Bruggemann, Jason, O’Donnell, Maryanne, Lenroot, Rhoshel, Guillemin, Gilles J., Weickert, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577855/ https://www.ncbi.nlm.nih.gov/pubmed/30940904 http://dx.doi.org/10.1038/s41380-019-0401-9

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