Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

Human regulatory T (T(reg)) cells are essential for immune homeostasis. The transcription factor (TF) FOXP3 maintains T(reg) cell identity, yet the complete set of key TFs that control T(reg) cell gene expression remains unknown. Here, we used pooled and arrayed Cas9 ribonucleoprotein (RNP) screens...

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Detalles Bibliográficos
Autores principales: Schumann, Kathrin, Raju, Siddharth S., Lauber, Michael, Kolb, Saskia, Shifrut, Eric, Cortez, Jessica T., Skartsis, Nikolaos, Nguyen, Vinh Q., Woo, Jonathan M., Roth, Theodore L., Yu, Ruby, Nguyen, Michelle L. T., Simeonov, Dimitre R., Nguyen, David N., Targ, Sasha, Gate, Rachel E., Tang, Qizhi, Bluestone, Jeffrey A., Spitzer, Matthew H., Ye, Chun Jimmie, Marson, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577958/
https://www.ncbi.nlm.nih.gov/pubmed/32989329
http://dx.doi.org/10.1038/s41590-020-0784-4

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