Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone

The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites,...

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Detalles Bibliográficos
Autores principales: Cheng, Gang, Hardy, Micael, Topchyan, Paytsar, Zander, Ryan, Volberding, Peter, Cui, Weiguo, Kalyanaraman, Balaraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578061/
https://www.ncbi.nlm.nih.gov/pubmed/33087770
http://dx.doi.org/10.1038/s41598-020-74808-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578061/
https://www.ncbi.nlm.nih.gov/pubmed/33087770
http://dx.doi.org/10.1038/s41598-020-74808-0

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