Cargando…

Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone

The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Gang, Hardy, Micael, Topchyan, Paytsar, Zander, Ryan, Volberding, Peter, Cui, Weiguo, Kalyanaraman, Balaraman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578061/ https://www.ncbi.nlm.nih.gov/pubmed/33087770 http://dx.doi.org/10.1038/s41598-020-74808-0

Ejemplares similares

Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects
por: Cheng, Gang, et al.
Publicado: (2021)

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
por: Cheng, Gang, et al.
Publicado: (2022)

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone
por: Huang, Mofei, et al.
Publicado: (2022)

Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells
por: Cheng, Gang, et al.
Publicado: (2023)

Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment
por: Cheng, Gang, et al.
Publicado: (2023)

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
por: Kalyanaraman, Balaraman, et al.
Publicado: (2022)

The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
por: Topchyan, Paytsar, et al.
Publicado: (2023)

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds
por: Zhang, Qi, et al.
Publicado: (2022)

Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection
por: Topchyan, Paytsar, et al.
Publicado: (2022)

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells
por: Cheng, Gang, et al.
Publicado: (2020)

Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators
por: Cheng, Gang, et al.
Publicado: (2019)

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
por: Kalyanaraman, Balaraman, et al.
Publicado: (2017)

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316–327]
por: Kalyanaraman, Balaraman, et al.
Publicado: (2018)

Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8(+) T Cells
por: Chen, Yao, et al.
Publicado: (2021)

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies
por: Kalyanaraman, Balaraman, et al.
Publicado: (2017)

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease
por: Kalyanaraman, Balaraman
Publicado: (2020)

Exploiting the tumor immune microenvironment and immunometabolism using mitochondria‐targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research
por: Kalyanaraman, Balaraman
Publicado: (2022)

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
por: Cheng, Gang, et al.
Publicado: (2019)

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
por: Ashton, Thomas M., et al.
Publicado: (2016)

Immunoregulatory Effects of Mitochondria Transferred by Extracellular Vesicles
por: She, Zhou, et al.
Publicado: (2021)

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
por: Pan, Jing, et al.
Publicado: (2018)

Harnessing the IL-21-BATF Pathway in the CD8(+) T Cell Anti-Tumor Response
por: Topchyan, Paytsar, et al.
Publicado: (2021)

Antimalarial pharmacology and therapeutics of atovaquone
por: Nixon, Gemma L., et al.
Publicado: (2013)

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death
por: Cheng, Gang, et al.
Publicado: (2013)

In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity
por: Montecino-Garrido, Héctor, et al.
Publicado: (2022)

Clonal lineage tracing reveals mechanisms skewing CD8(+) T cell fate decisions in chronic infection
por: Kasmani, Moujtaba Y., et al.
Publicado: (2022)

1895. The Anti-Parasitic Drug Atovaquone Inhibits Arbovirus Replication
por: Kottkamp, Angelica, et al.
Publicado: (2018)

Atovaquone/proguanil‐induced autoimmune‐like hepatitis
por: Terziroli Beretta‐Piccoli, Benedetta, et al.
Publicado: (2017)

Reversible Cerebral Vasoconstriction Syndrome due to Atovaquone
por: Makino, Takahiro, et al.
Publicado: (2017)

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms()
por: Kalyanaraman, Balaraman
Publicado: (2013)

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
por: Kalyanaraman, Balaraman
Publicado: (2017)

Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity?
por: Kalyanaraman, Balaraman
Publicado: (2020)

Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree?
por: Kalyanaraman, Balaraman
Publicado: (2019)

Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: overlapping biology with cancer
por: Kalyanaraman, Balaraman
Publicado: (2021)

NAC, NAC, Knockin’ on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells
por: Kalyanaraman, Balaraman
Publicado: (2022)

Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
por: Huang, Minmin, et al.
Publicado: (2021)

Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice
por: Tseng, Han-Ching, et al.
Publicado: (2015)

Plasmodium falciparum Malaria and Atovaquone-Proguanil Treatment Failure
por: Durand, Rémy, et al.
Publicado: (2008)

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
por: Bakshi, Rahul P., et al.
Publicado: (2018)

Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria
por: Blanshard, Andrew, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v74pajnkidlvqmirp3dq63jktc