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Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung
Foxp3(+) regulatory T (T(reg)) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T(reg) cells also respond to the alarmin IL-33 to regulate specific aspects of the immune response is not known. Here we describe an unexpected function of ST2(+)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578082/ https://www.ncbi.nlm.nih.gov/pubmed/32989331 http://dx.doi.org/10.1038/s41590-020-0785-3 |
Sumario: | Foxp3(+) regulatory T (T(reg)) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T(reg) cells also respond to the alarmin IL-33 to regulate specific aspects of the immune response is not known. Here we describe an unexpected function of ST2(+) T(reg) cells in suppressing the innate immune response in the lung to environmental allergens without altering the adaptive immune response. Following allergen exposure, ST2(+) T(reg) cells were activated by IL-33 to suppress IL-17-producing γδ T cells. ST2 signaling in T(reg) cells induced Ebi3, a component of the heterodimeric cytokine IL-35 that was required for T(reg) cell-mediated suppression of γδ T cells. This response resulted in less eosinophil-attracting chemokines and reduced eosinophil recruitment into the lung, which was beneficial to the host in reducing inflammation induced by allergen. Thus, we define a fundamental role for ST2(+) T(reg) cells in the lung as a negative regulator of the early innate γδ T cell response to mucosal injury. |
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