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Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung
Foxp3(+) regulatory T (T(reg)) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T(reg) cells also respond to the alarmin IL-33 to regulate specific aspects of the immune response is not known. Here we describe an unexpected function of ST2(+)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578082/ https://www.ncbi.nlm.nih.gov/pubmed/32989331 http://dx.doi.org/10.1038/s41590-020-0785-3 |
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author | Faustino, Lucas D. Griffith, Jason W. Rahimi, Rod A. Nepal, Keshav Hamilos, Daniel L. Cho, Josalyn L. Medoff, Benjamin D. Moon, James J. Vignali, Dario A.A. Luster, Andrew D. |
author_facet | Faustino, Lucas D. Griffith, Jason W. Rahimi, Rod A. Nepal, Keshav Hamilos, Daniel L. Cho, Josalyn L. Medoff, Benjamin D. Moon, James J. Vignali, Dario A.A. Luster, Andrew D. |
author_sort | Faustino, Lucas D. |
collection | PubMed |
description | Foxp3(+) regulatory T (T(reg)) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T(reg) cells also respond to the alarmin IL-33 to regulate specific aspects of the immune response is not known. Here we describe an unexpected function of ST2(+) T(reg) cells in suppressing the innate immune response in the lung to environmental allergens without altering the adaptive immune response. Following allergen exposure, ST2(+) T(reg) cells were activated by IL-33 to suppress IL-17-producing γδ T cells. ST2 signaling in T(reg) cells induced Ebi3, a component of the heterodimeric cytokine IL-35 that was required for T(reg) cell-mediated suppression of γδ T cells. This response resulted in less eosinophil-attracting chemokines and reduced eosinophil recruitment into the lung, which was beneficial to the host in reducing inflammation induced by allergen. Thus, we define a fundamental role for ST2(+) T(reg) cells in the lung as a negative regulator of the early innate γδ T cell response to mucosal injury. |
format | Online Article Text |
id | pubmed-7578082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-75780822021-03-28 Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung Faustino, Lucas D. Griffith, Jason W. Rahimi, Rod A. Nepal, Keshav Hamilos, Daniel L. Cho, Josalyn L. Medoff, Benjamin D. Moon, James J. Vignali, Dario A.A. Luster, Andrew D. Nat Immunol Article Foxp3(+) regulatory T (T(reg)) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T(reg) cells also respond to the alarmin IL-33 to regulate specific aspects of the immune response is not known. Here we describe an unexpected function of ST2(+) T(reg) cells in suppressing the innate immune response in the lung to environmental allergens without altering the adaptive immune response. Following allergen exposure, ST2(+) T(reg) cells were activated by IL-33 to suppress IL-17-producing γδ T cells. ST2 signaling in T(reg) cells induced Ebi3, a component of the heterodimeric cytokine IL-35 that was required for T(reg) cell-mediated suppression of γδ T cells. This response resulted in less eosinophil-attracting chemokines and reduced eosinophil recruitment into the lung, which was beneficial to the host in reducing inflammation induced by allergen. Thus, we define a fundamental role for ST2(+) T(reg) cells in the lung as a negative regulator of the early innate γδ T cell response to mucosal injury. 2020-09-28 2020-11 /pmc/articles/PMC7578082/ /pubmed/32989331 http://dx.doi.org/10.1038/s41590-020-0785-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Faustino, Lucas D. Griffith, Jason W. Rahimi, Rod A. Nepal, Keshav Hamilos, Daniel L. Cho, Josalyn L. Medoff, Benjamin D. Moon, James J. Vignali, Dario A.A. Luster, Andrew D. Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung |
title | Interleukin-33 activates regulatory T cells to suppress innate
γδ T cell responses in the lung |
title_full | Interleukin-33 activates regulatory T cells to suppress innate
γδ T cell responses in the lung |
title_fullStr | Interleukin-33 activates regulatory T cells to suppress innate
γδ T cell responses in the lung |
title_full_unstemmed | Interleukin-33 activates regulatory T cells to suppress innate
γδ T cell responses in the lung |
title_short | Interleukin-33 activates regulatory T cells to suppress innate
γδ T cell responses in the lung |
title_sort | interleukin-33 activates regulatory t cells to suppress innate
γδ t cell responses in the lung |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578082/ https://www.ncbi.nlm.nih.gov/pubmed/32989331 http://dx.doi.org/10.1038/s41590-020-0785-3 |
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