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Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study

BACKGROUND AND AIMS: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects. METHODS: A sample o...

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Autores principales: Firbank, Michael J., O’Brien, John T., Ritchie, Karen, Wells, Katie, Williams, Guy, Su, Li, Ritchie, Craig W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578123/
https://www.ncbi.nlm.nih.gov/pubmed/32564151
http://dx.doi.org/10.1007/s00415-020-10000-8
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author Firbank, Michael J.
O’Brien, John T.
Ritchie, Karen
Wells, Katie
Williams, Guy
Su, Li
Ritchie, Craig W.
author_facet Firbank, Michael J.
O’Brien, John T.
Ritchie, Karen
Wells, Katie
Williams, Guy
Su, Li
Ritchie, Craig W.
author_sort Firbank, Michael J.
collection PubMed
description BACKGROUND AND AIMS: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects. METHODS: A sample of 162 subjects (aged 40–59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM. RESULTS: Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this. CONCLUSIONS: We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40–60-year-olds.
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spelling pubmed-75781232020-10-27 Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study Firbank, Michael J. O’Brien, John T. Ritchie, Karen Wells, Katie Williams, Guy Su, Li Ritchie, Craig W. J Neurol Original Communication BACKGROUND AND AIMS: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects. METHODS: A sample of 162 subjects (aged 40–59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM. RESULTS: Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this. CONCLUSIONS: We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40–60-year-olds. Springer Berlin Heidelberg 2020-06-20 2020 /pmc/articles/PMC7578123/ /pubmed/32564151 http://dx.doi.org/10.1007/s00415-020-10000-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Communication
Firbank, Michael J.
O’Brien, John T.
Ritchie, Karen
Wells, Katie
Williams, Guy
Su, Li
Ritchie, Craig W.
Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title_full Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title_fullStr Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title_full_unstemmed Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title_short Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study
title_sort midlife alcohol consumption and longitudinal brain atrophy: the prevent-dementia study
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578123/
https://www.ncbi.nlm.nih.gov/pubmed/32564151
http://dx.doi.org/10.1007/s00415-020-10000-8
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