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Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study

For people with disordered consciousness (DoC) after traumatic brain injury (TBI), relationships between treatment-induced changes in neural connectivity and neurobehavioral recovery have not been explored. To begin building a body of evidence regarding the unique contributions of treatments to chan...

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Autores principales: Bender Pape, Theresa L., Livengood, Sherri L., Kletzel, Sandra L., Blabas, Brett, Guernon, Ann, Bhaumik, Dulal K., Bhaumik, Runa, Mallinson, Trudy, Weaver, Jennifer A., Higgins, James P., Wang, Xue, Herrold, Amy A., Rosenow, Joshua M., Parrish, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578344/
https://www.ncbi.nlm.nih.gov/pubmed/33132997
http://dx.doi.org/10.3389/fneur.2020.01027
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author Bender Pape, Theresa L.
Livengood, Sherri L.
Kletzel, Sandra L.
Blabas, Brett
Guernon, Ann
Bhaumik, Dulal K.
Bhaumik, Runa
Mallinson, Trudy
Weaver, Jennifer A.
Higgins, James P.
Wang, Xue
Herrold, Amy A.
Rosenow, Joshua M.
Parrish, Todd
author_facet Bender Pape, Theresa L.
Livengood, Sherri L.
Kletzel, Sandra L.
Blabas, Brett
Guernon, Ann
Bhaumik, Dulal K.
Bhaumik, Runa
Mallinson, Trudy
Weaver, Jennifer A.
Higgins, James P.
Wang, Xue
Herrold, Amy A.
Rosenow, Joshua M.
Parrish, Todd
author_sort Bender Pape, Theresa L.
collection PubMed
description For people with disordered consciousness (DoC) after traumatic brain injury (TBI), relationships between treatment-induced changes in neural connectivity and neurobehavioral recovery have not been explored. To begin building a body of evidence regarding the unique contributions of treatments to changes in neural network connectivity relative to neurobehavioral recovery, we conducted a pilot study to identify relationships meriting additional examination in future research. To address this objective, we examined previously unpublished neural connectivity data derived from a randomized clinical trial (RCT). We leveraged these data because treatment efficacy, in the RCT, was based on a comparison of a placebo control with a specific intervention, the familiar auditory sensory training (FAST) intervention, consisting of autobiographical auditory-linguistic stimuli. We selected a subgroup of RCT participants with high-quality imaging data (FAST n = 4 and placebo n = 4) to examine treatment-related changes in brain network connectivity and how and if these changes relate to neurobehavioral recovery. To discover promising relationships among the FAST intervention, changes in neural connectivity, and neurobehavioral recovery, we examined 26 brain regions and 19 white matter tracts associated with default mode, salience, attention, and language networks, as well as three neurobehavioral measures. Of the relationships discovered, the systematic filtering process yielded evidence supporting further investigation of the relationship among the FAST intervention, connectivity of the left inferior longitudinal fasciculus, and auditory-language skills. Evidence also suggests that future mechanistic research should focus on examining the possibility that the FAST supports connectivity changes by facilitating redistribution of brain resources. For a patient population with limited treatment options, the reported findings suggest that a simple, yet targeted, passive sensory stimulation treatment may have altered functional and structural connectivity. If replicated in future research, then these findings provide the foundation for characterizing the unique contributions of the FAST intervention and could inform development of new treatment strategies. For persons with severely damaged brain networks, this report represents a first step toward advancing understanding of the unique contributions of treatments to changing brain network connectivity and how these changes relate to neurobehavioral recovery for persons with DoC after TBI. Clinical Trial Registry: NCT00557076, The Efficacy of Familiar Voice Stimulation During Coma Recovery (http://www.clinicaltrials.gov).
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spelling pubmed-75783442020-10-30 Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study Bender Pape, Theresa L. Livengood, Sherri L. Kletzel, Sandra L. Blabas, Brett Guernon, Ann Bhaumik, Dulal K. Bhaumik, Runa Mallinson, Trudy Weaver, Jennifer A. Higgins, James P. Wang, Xue Herrold, Amy A. Rosenow, Joshua M. Parrish, Todd Front Neurol Neurology For people with disordered consciousness (DoC) after traumatic brain injury (TBI), relationships between treatment-induced changes in neural connectivity and neurobehavioral recovery have not been explored. To begin building a body of evidence regarding the unique contributions of treatments to changes in neural network connectivity relative to neurobehavioral recovery, we conducted a pilot study to identify relationships meriting additional examination in future research. To address this objective, we examined previously unpublished neural connectivity data derived from a randomized clinical trial (RCT). We leveraged these data because treatment efficacy, in the RCT, was based on a comparison of a placebo control with a specific intervention, the familiar auditory sensory training (FAST) intervention, consisting of autobiographical auditory-linguistic stimuli. We selected a subgroup of RCT participants with high-quality imaging data (FAST n = 4 and placebo n = 4) to examine treatment-related changes in brain network connectivity and how and if these changes relate to neurobehavioral recovery. To discover promising relationships among the FAST intervention, changes in neural connectivity, and neurobehavioral recovery, we examined 26 brain regions and 19 white matter tracts associated with default mode, salience, attention, and language networks, as well as three neurobehavioral measures. Of the relationships discovered, the systematic filtering process yielded evidence supporting further investigation of the relationship among the FAST intervention, connectivity of the left inferior longitudinal fasciculus, and auditory-language skills. Evidence also suggests that future mechanistic research should focus on examining the possibility that the FAST supports connectivity changes by facilitating redistribution of brain resources. For a patient population with limited treatment options, the reported findings suggest that a simple, yet targeted, passive sensory stimulation treatment may have altered functional and structural connectivity. If replicated in future research, then these findings provide the foundation for characterizing the unique contributions of the FAST intervention and could inform development of new treatment strategies. For persons with severely damaged brain networks, this report represents a first step toward advancing understanding of the unique contributions of treatments to changing brain network connectivity and how these changes relate to neurobehavioral recovery for persons with DoC after TBI. Clinical Trial Registry: NCT00557076, The Efficacy of Familiar Voice Stimulation During Coma Recovery (http://www.clinicaltrials.gov). Frontiers Media S.A. 2020-10-08 /pmc/articles/PMC7578344/ /pubmed/33132997 http://dx.doi.org/10.3389/fneur.2020.01027 Text en Copyright © 2020 Bender Pape, Livengood, Kletzel, Blabas, Guernon, Bhaumik, Bhaumik, Mallinson, Weaver, Higgins, Wang, Herrold, Rosenow and Parrish. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Bender Pape, Theresa L.
Livengood, Sherri L.
Kletzel, Sandra L.
Blabas, Brett
Guernon, Ann
Bhaumik, Dulal K.
Bhaumik, Runa
Mallinson, Trudy
Weaver, Jennifer A.
Higgins, James P.
Wang, Xue
Herrold, Amy A.
Rosenow, Joshua M.
Parrish, Todd
Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title_full Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title_fullStr Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title_full_unstemmed Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title_short Neural Connectivity Changes Facilitated by Familiar Auditory Sensory Training in Disordered Consciousness: A TBI Pilot Study
title_sort neural connectivity changes facilitated by familiar auditory sensory training in disordered consciousness: a tbi pilot study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578344/
https://www.ncbi.nlm.nih.gov/pubmed/33132997
http://dx.doi.org/10.3389/fneur.2020.01027
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