Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown. We hypothesized that estrogen signaling may be responsible, despite t...

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Detalles Bibliográficos
Autores principales: Natale, Christopher A., Li, Jinyang, Pitarresi, Jason R., Norgard, Robert J., Dentchev, Tzvete, Capell, Brian C., Seykora, John T., Stanger, Ben Z., Ridky, Todd W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578406/
https://www.ncbi.nlm.nih.gov/pubmed/32376419
http://dx.doi.org/10.1016/j.jcmgh.2020.04.016

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